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Trends were evaluated by calculating the estimated annual percentage change (EAPC). Joinpoint regression analysis was used to detect changes in trends. Cervical intraepithelial neoplasia (CIN) detection rates were calculated by data from \u201cthe nationwide network and registry of histo\u2010 and cytopathology\u201d during 1990\u20132006. Total age\u2010adjusted incidence rate (European standardized rate (ESR)) was 7.9 per 100,000 woman years in 2007. During 1989\u20131998, incidence rates decreased with an EAPC of \u22121.3% (95% confidence interval (CI) \u22122.2 to \u22120.3), during 1998\u20132001 with \u22126.7% (95% CI: \u221216.4 to 4.1), and increased during 2001\u20132007 with 2.3% (95% CI: 0.4 to 4.2). Total mortality ESR was 1.9 per 100,000 woman years in 2007. Mortality rates decreased during 1970\u20131994 annually with \u22124.1% (95% CI: \u22124.6% to \u22123.7%), and with \u22122.6% (95% CI: \u22123.8% to \u22121.5%) during 1994\u20132007. The observed trend in total incidence is similar to the trend in squamous cell carcinomas in age group 35\u201354 years, suggesting that the observed trends are likely to be associated to changes in the screening program. This is supported by the trend in CINIII detection rates. In conclusion, incidence and mortality overall decreased and leveled off. On top of that there was an extra decrease that was compensated by a following recent increase in incidence, probably resulting from reorganization of the Dutch screening program.<\/jats:p>","DOI":"10.1002\/ijc.25553","type":"journal-article","created":{"date-parts":[[2010,7,12]],"date-time":"2010-07-12T15:35:03Z","timestamp":1278948903000},"page":"2174-2181","source":"Crossref","is-referenced-by-count":46,"title":["Trends in cervical cancer in the Netherlands until 2007: Has the bottom been reached?"],"prefix":"10.1002","volume":"128","author":[{"given":"Inge M.C.M.","family":"de Kok","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maaike A.","family":"van der Aa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjolein","family":"van Ballegooijen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Siesling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrike E.","family":"Karim\u2010Kos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Folkert J.","family":"van Kemenade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan Willem W.","family":"Coebergh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the Working Group Output of the Netherlands Cancer Registry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,3,8]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"Netherlands Cancer Registry. 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