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We wished to assess safety and health care resource use of a real\u2010life health care policy using HPV triaging. All 15 outpatient clinics involved in the organized population\u2010based screening program in Stockholm, Sweden screening program were randomized to either continue with prior policy (colposcopy of all women with ASCUS\/CINI) or to implement a policy with HPV triaging and colposcopy only of HPV\u2010positive women. The trial enrolled the 3,319 women who were diagnosed with ASCUS (<jats:italic>n<\/jats:italic> = 1,335) or CINI (<jats:italic>n<\/jats:italic> = 1,984) in Stockholm during 17th March 2003 to 16th January 2006. Detection of high\u2010grade cervical lesions (CINII+) and health care cost consumption was studied by registry linkages. The proportion of histopathology\u2010verified CINII+ was similar for the two policies (395 of 1,752 women (22.5%; 95% Confidence interval [CI]: 20.6\u201324.6%) had CINII+ diagnosed with HPV triaging policy, 318 of 1,567 women (20.3%; 95%CI: 18.3\u201322.4%) had CINII+ with colposcopy policy). Sixty\u2010four percent of women with ASCUS and 77% of women with CINI were HPV positive. HPV\u2010positivity was age\u2010dependent, with 81% of women below 35 years of age and 44% of women above 45 years of age testing HPV\u2010positive. HPV triaging was cost\u2010effective only above 35 years of age. In conclusion, a real\u2010life randomized healthservices study of HPV triaging of women with ASCUS\/CINI demonstrated similar detection of CINII+ as colposcopy of all women.<\/jats:p>","DOI":"10.1002\/ijc.25649","type":"journal-article","created":{"date-parts":[[2010,9,8]],"date-time":"2010-09-08T04:18:27Z","timestamp":1283919507000},"page":"151-159","source":"Crossref","is-referenced-by-count":16,"title":["Randomized healthservices study of human papillomavirus\u2010based management of low\u2010grade cytological 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