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The coexistence of a large B\u2010cell lymphoma and a MALT lymphoma in the gastrointestinal tract is defined as a composite lymphoma (ComL) and, as we have previously shown, is almost always the consequence of secondary transformation of MALT lymphoma. Here, we have analyzed a panel of seven MALT lymphomas, seven ComL and thirteen large cell variants of marginal zone B\u2010cell lymphomas (MZBL) using FISH for the detection of rearrangements of <jats:italic>IGH, MALT1, BCL6, BCL10<\/jats:italic> and <jats:italic>FOXP1<\/jats:italic> and immunohistochemistry for Bcl6, Bcl10 and FoxP1. Translocations involving <jats:italic>IGH<\/jats:italic> were found in 10\/27 lymphomas including two cases with <jats:italic>IGH\u2010BCL6<\/jats:italic> fusion and one with <jats:italic>IGH\u2010BCL10<\/jats:italic> fusion; in 7\/10 cases, the translocation partner was not identified. Bcl10 and FoxP1 protein expression was heterogeneous throughout the series. Genetic rearrangements of <jats:italic>BCL6<\/jats:italic> and Bcl6 protein expression were found almost exclusively in the large cell components of the ComL and the large cell extranodal MZBL (<jats:italic>p<\/jats:italic> = 0.2093 and <jats:italic>p<\/jats:italic> = 0.0261, respectively). These findings suggest Bcl6 as a marker for transformation of MALT lymphoma.<\/jats:p>","DOI":"10.1002\/ijc.25663","type":"journal-article","created":{"date-parts":[[2010,9,9]],"date-time":"2010-09-09T14:46:08Z","timestamp":1284043568000},"page":"70-77","source":"Crossref","is-referenced-by-count":37,"title":["<i>BCL6<\/i> gene rearrangement and protein expression are associated with large cell presentation of extranodal marginal zone B\u2010cell lymphoma of mucosa\u2010associated lymphoid 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