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Data were extracted from the nationwide Cancer Registry database. To assess the possible impact of HPV infection, the sites of squamous cell carcinomas were categorized as HPV\u2010associated, potentially HPV\u2010associated or HPV\u2010unrelated. In total, 26,474 incident cases were identified and the overall incidence increased throughout the period. Significantly increasing incidence rates were notably seen for tumors in the oral cavity (2.2% per year), tonsils (4.8% per year), oropharynx (3.5% per year) and hypopharynx (4.4% per year). A significantly decreasing incidence of lip cancer was observed among men (\u20135.0% per year). Cancers at HPV\u2010associated sites (<jats:italic>n<\/jats:italic> = 3650) showed strongly increasing incidence rates, primarily in individuals &lt; 60 years. In contrast, HNCs at sites not related to HPV infection showed a significant decrease (in men) or virtually no change in incidence (in women). Our results suggest a marked impact of HPV infection on the epidemiology of HNCs in Denmark. HPV16 is the type most often found in HNCs; thus, the recent introduction of vaccination against HPV may in the future prevent HPV\u2010associated cancers of the head and neck.<\/jats:p>","DOI":"10.1002\/ijc.25699","type":"journal-article","created":{"date-parts":[[2010,9,28]],"date-time":"2010-09-28T14:50:13Z","timestamp":1285685413000},"page":"733-741","source":"Crossref","is-referenced-by-count":178,"title":["Trends in head and neck cancer incidence in Denmark, 1978\u20132007: Focus on human papillomavirus associated sites"],"prefix":"10.1002","volume":"129","author":[{"given":"Maria","family":"Blomberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Munk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne Kr\u00fcger","family":"Kjaer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,10,26]]},"reference":[{"key":"e_1_2_6_2_2","series-title":"The Danish cancer registry 2008","author":"National Board of Health","year":"2009"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21140"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.05.111"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20740"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23745"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.12.009"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016480601110170"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djg107"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22633"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24339"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10577"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2000.290702.x"},{"key":"e_1_2_6_14_2","article-title":"Head and neck cancer in Germany: a site\u2010specific analysis of survival of the Thuringian cancer registration database","author":"Guntinas\u2010Lichius O","journal-title":"J Cancer Res Clin Oncol"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2009.03.010"},{"key":"e_1_2_6_16_2","unstructured":"Statistics Denmark. 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