{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:03:09Z","timestamp":1761919389663},"reference-count":44,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2010,11,28]],"date-time":"2010-11-28T00:00:00Z","timestamp":1290902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>C\u2010reactive protein (CRP), a biomarker of inflammation, has been shown to be influenced by genetic variation in the <jats:italic>CRP<\/jats:italic> gene. In this study, we test the hypothesis that genetic variation in <jats:italic>CRP<\/jats:italic> influences both the risk of developing colon and rectal cancer and survival. Two population\u2010based studies of colon cancer (<jats:italic>n<\/jats:italic> = 1,574 cases, 1,970 controls) and rectal (<jats:italic>n<\/jats:italic> = 791 cases, 999 controls) were conducted. We evaluated four <jats:italic>CRP<\/jats:italic> tagSNPs: rs1205 (<jats:italic>G<\/jats:italic> &gt; <jats:italic>A<\/jats:italic>, 3\u2032 UTR); rs1417938 (<jats:italic>T<\/jats:italic> &gt; <jats:italic>A<\/jats:italic>, intron); rs1800947 (<jats:italic>G<\/jats:italic> &gt; <jats:italic>C<\/jats:italic>, L184L); and rs3093075 (<jats:italic>C<\/jats:italic> &gt; <jats:italic>A<\/jats:italic>, 3\u2032 flanking). The <jats:italic>CRP<\/jats:italic> rs1205 AA genotype was associated with an increased risk of colon cancer (OR 1.3, 95%CI 1.1\u20131.7), whereas the rs3093075 A allele was associated with a reduced risk of rectal cancer (OR 0.7, 95%CI 0.5\u20130.9). The strongest association for the rs1205 polymorphism and colon cancer was observed among those with <jats:italic>KRAS2<\/jats:italic> mutations (OR 1.5, 95%CI 1.1\u20132.0). The <jats:italic>CRP<\/jats:italic> rs1205 AA genotype also was associated with an increased risk of CIMP+ rectal tumors (OR 2.5, 95%CI 1.2\u20135.3); conversely, the rs1417938 A allele was associated with a reduced risk of CIMP+ rectal tumors (OR 0.5, 95%CI 0.3\u20130.9). We observed interactions between <jats:italic>CRP<\/jats:italic> rs1800947 and BMI and family history of CRC in modifying risk of both colon and rectal cancer. These data suggest that genetic variation in the <jats:italic>CRP<\/jats:italic> gene influences risk of both colon and rectal cancer development.<\/jats:p>","DOI":"10.1002\/ijc.25721","type":"journal-article","created":{"date-parts":[[2010,10,14]],"date-time":"2010-10-14T17:31:51Z","timestamp":1287077511000},"page":"2726-2734","source":"Crossref","is-referenced-by-count":45,"title":["Genetic variation in C\u2010reactive protein in relation to colon and rectal cancer risk and survival"],"prefix":"10.1002","volume":"128","author":[{"given":"Martha L.","family":"Slattery","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Curtin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth M.","family":"Poole","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David 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