{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T23:50:11Z","timestamp":1780530611299,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2011,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Screen\u2010and\u2010treat cervical cancer prevention programs based on high\u2010risk human papillomavirus (HPV) testing and cryotherapy have been shown to be effective in resource\u2010limited settings. However, because cryotherapy is not 100% effective, follow\u2010up is needed after treatment to detect post\u2010treatment failures. We compared the test performances of high\u2010risk HPV testing (Hybrid Capture 2) using self\u2010collected and clinician\u2010collected samples as well as cervical cytology for identifying cervical intraepithelial neoplasia grades 2 or 3 or invasive cervical cancer (CIN2+) among women who did (<jats:italic>n<\/jats:italic> = 812) and did not (<jats:italic>n<\/jats:italic> = 1858) undergo cryotherapy in a South African screen\u2010and\u2010treat trial. At 6 months after enrolment (and after cryotherapy, if performed), women were tested using all three screening methods and then underwent colposcopy\/biopsy. A predefined subset of women (<jats:italic>n<\/jats:italic> = 1,455) had extended follow\u2010up with colposcopy\/biopsy at 12 months. A total of 33 and 91 cases of CIN2+ were detected among treated and untreated women, respectively. The sensitivity of HPV testing using clinician\u2010collected samples and cervical cytology did not differ by treatment status. HPV testing of clinician\u2010collected samples detected the most cases of CIN2+ among both treated (85%) and untreated (91%) women (<jats:italic>p<\/jats:italic> = 0.31). Cytology (at a cutoff of atypical squamous cells of undetermined significance or greater) detected 76% of cases among both treated and untreated women. However, the sensitivity of HPV testing using self\u2010collected samples was significantly lower among treated versus untreated women (55% vs. 78%, <jats:italic>p<\/jats:italic> = 0.01). HPV testing using self\u2010collected vaginal specimens may be useful in primary screening but performs poorly for detecting post\u2010treatment failures.<\/jats:p>","DOI":"10.1002\/ijc.25731","type":"journal-article","created":{"date-parts":[[2010,10,18]],"date-time":"2010-10-18T14:18:34Z","timestamp":1287411514000},"page":"879-886","source":"Crossref","is-referenced-by-count":22,"title":["A comparison of human papillomavirus testing of clinician\u2010collected and self\u2010collected samples during follow\u2010up after screen\u2010and\u2010treat"],"prefix":"10.1002","volume":"129","author":[{"given":"Sylvia","family":"Taylor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas 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