{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:59:19Z","timestamp":1789156759004,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,2,11]],"date-time":"2011-02-11T00:00:00Z","timestamp":1297382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2011,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this case\u2013control study was to examine if type\u2010specific human papillomavirus (HPV) DNA geno\u2010typing before and after treatment of high\u2010grade cervical intra\u2010epithelial neoplasia (CIN) improves prediction of recurring or persisting CIN 2 or 3 compared with follow\u2010up cytology or high\u2010risk (hr)HPV testing. Women with biopsy\u2010proven recurrence of CIN 2 or 3 (cases) in a follow\u2010up period of at least 24 months after treatment of high\u2010grade CIN were compared with women without recurrence (controls). These cohorts were identified by a database search of the Riatol Laboratoria (Antwerp, Belgium). In a cohort of 823 women treated with conisation for high\u2010grade CIN between January 2001 and December 2007, 21 patients with a histologically proven recurrence of CIN2+ were identified. A group of women (<jats:italic>n<\/jats:italic> = 42) from the same cohort without recurrence was randomly chosen. We found that hrHPV testing at 6 months post\u2010treatment is significantly more sensitive compared with follow\u2010up cytology (ratio: 1.31, 95% confidence interval (CI): 1.10\u20131.54), but less specific (ratio: 0.85, 95% CI: 0.81\u20130.90) to predict failure of treatment. When compared with hrHPV testing, HPV geno\u2010typing is more efficient (equal sensitivity, but higher specificity, ratio: 1.43, 95% CI: 1.280\u20131.62). When compared with follow\u2010up cytology, HPV geno\u2010typing is more sensitive (ratio: 1.31, 95% CI: 1.10\u20131.54) and more specific (ratio: 1.22, 95% CI: 1.14\u20131.36). All women who developed a recurrence tested positive for hrHPV. The negative predictive value in the absence of hrHPV DNA was 100%. Six months after treatment HPV geno\u2010typing is the most sensitive and specific method to predict recurrent or persistent CIN 2\u20103 in the next 24 months.<\/jats:p>","DOI":"10.1002\/ijc.25745","type":"journal-article","created":{"date-parts":[[2010,11,9]],"date-time":"2010-11-09T16:13:23Z","timestamp":1289319203000},"page":"903-909","source":"Crossref","is-referenced-by-count":47,"title":["Type\u2010specific HPV geno\u2010typing improves detection of recurrent high\u2010grade cervical neoplasia after conisation"],"prefix":"10.1002","volume":"129","author":[{"given":"Julie","family":"Heymans","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina H.","family":"Benoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willy","family":"Poppe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe E.","family":"Depuydt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,2,11]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.6.506"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.325.7364.572"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.55.4.244"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.3.252"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.05.117"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-200407000-00024"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)12490-X"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2005.07.033"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1438.1999.99066.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01063.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.04.016"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2003.07.008"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.01.005"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-8258(03)00415-3"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1997.4753"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2008.00636.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2007.00464.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000330870"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1159\/000331546"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.16.2114"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2007.00469.x"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600756"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2006.00386.x"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2007.00073.x"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021641"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-2607(95)01703-8"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0845"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1998.5250"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2000.5952"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)08295-5"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1689"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.10.011"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.25745","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.25745","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T05:06:50Z","timestamp":1697432810000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.25745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,11]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,8,15]]}},"alternative-id":["10.1002\/ijc.25745"],"URL":"https:\/\/doi.org\/10.1002\/ijc.25745","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,11]]}}}