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An inverse correlation was demonstrated between expression levels of WAVE3 and miR\u201031 in invasive <jats:italic>versus<\/jats:italic> noninvasive breast cancer cell lines. miR\u201031 directly targeted the 3'\u2010UTR of the <jats:italic>WAVE3<\/jats:italic> mRNA and inhibited its expression in the invasive cancer cells, <jats:italic>i.e<\/jats:italic>., miR\u201031\u2010mediated down\u2010regulation of WAVE3 resulted in a significant reduction in the invasive phenotype of cancer cells. This relationship was specific to the loss of WAVE3 expression because re\u2010expression of a miR\u201031\u2010resistant form of WAVE3 reversed miR\u201031\u2010mediated inhibition of cancer cell invasion. Furthermore, expression of miR\u201031 correlates inversely with breast cancer progression in humans, where an increase in expression of miR\u201031 target genes was observed as the tumors progressed to more aggressive forms. In conclusion, a novel mechanism for the regulation of WAVE3 expression in cancer cells has been identified, which controls the invasive properties of cancer cells. The study also identifies a critical role for WAVE3, downstream of miR\u201031, in the invasion\u2010metastasis cascade.<\/jats:p>","DOI":"10.1002\/ijc.25793","type":"journal-article","created":{"date-parts":[[2010,11,24]],"date-time":"2010-11-24T09:57:22Z","timestamp":1290592642000},"page":"1331-1343","source":"Crossref","is-referenced-by-count":80,"title":["WAVE3, an actin remodeling protein, is regulated by the metastasis suppressor microRNA, miR\u201031, during the invasion\u2010metastasis 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