{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:40:14Z","timestamp":1789191614169,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2011,2,26]],"date-time":"2011-02-26T00:00:00Z","timestamp":1298678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2011,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Experimental studies suggest a role for aspirin in the chemoprevention of prostate cancer and epidemiological evidence supports a modest inverse association between regular aspirin use and prostate cancer risk, especially for advanced disease. In a prospective cohort study of 51,529 health professionals aged 40\u201375 years at baseline, we evaluated long\u2010term aspirin use and the incidence of total, high\u2010grade (Gleason 8\u201010, <jats:italic>n<\/jats:italic> = 488), regionally advanced (T3b\u2010T4 or N1, <jats:italic>n<\/jats:italic> = 228) and lethal prostate cancer (M1, bony metastases or prostate cancer death, <jats:italic>n<\/jats:italic> = 580) from 1988\u20132006. We used Cox proportional hazards regression to evaluate risk associated with frequency (days\/week), quantity (tablets\/week), recency and duration of aspirin use after multivariable adjustment for confounders and other predictors of prostate cancer risk. A total of 4,858 men were diagnosed with prostate cancer during the 18\u2010year study period. Men taking \u2265 2 adult\u2010strength aspirin tablets a week had a 10% lower risk of prostate cancer (<jats:italic>p<\/jats:italic>\u2010for\u2010trend = 0.02). For regionally advanced cancer, we observed no significant associations with aspirin use. For high\u2010grade and lethal disease, men taking \u2265 6 adult\u2010strength tablets\/week experienced similar reductions in risk hazard ratio [HR = 0.72 (95% confidence intervals [CI]: 0.54, 0.96) and HR = 0.71 (95% CI: 0.50, 1.00)]. Analytical approaches to address bias from more frequent prostate\u2010specific antigen screening among aspirin users did not yield different conclusions. We observed reductions in the risk of high\u2010grade and lethal prostate cancer associated with higher doses of aspirin, but not with greater frequency or duration, in a large, prospective cohort of health professionals. Our data support earlier observations of modest inverse associations with advanced prostate cancer.<\/jats:p>","DOI":"10.1002\/ijc.25811","type":"journal-article","created":{"date-parts":[[2010,12,2]],"date-time":"2010-12-02T14:52:39Z","timestamp":1291301559000},"page":"2444-2452","source":"Crossref","is-referenced-by-count":42,"title":["Long\u2010term aspirin use and the risk of total, high\u2010grade, regionally advanced and lethal prostate cancer in a prospective cohort of health professionals, 1988\u20132006"],"prefix":"10.1002","volume":"128","author":[{"given":"Preet K.","family":"Dhillon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey A.","family":"Kenfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meir J.","family":"Stampfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward L.","family":"Giovannucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,2,26]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-2422"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.15.11397"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(02)00524-4"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(99)00200-2"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0045(20000215)42:3<172::AID-PROS2>3.0.CO;2-R"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.140.11.5451"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-3-28"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601416"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.649.13.4"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djk132"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11250"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015788502099"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji173"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19980812)77:4<511::AID-IJC6>3.0.CO;2-X"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.2000.00507.x"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0748-5514(85)90131-X"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008859729045"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2003.12.014"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-200301000-00007"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M408796200"},{"key":"e_1_2_7_22_2","first-page":"1108","article-title":"Aspirin use in relation to risk of prostate cancer","volume":"11","author":"Leitzmann MF","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116211"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990210521"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113804"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-121-4-199408150-00001"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067208"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199601000-00014"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22788"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0457"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-6257"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1080\/01635580701684864"},{"key":"e_1_2_7_33_2","first-page":"1","article-title":"Fish intake and the risk of fatal prostate cancer: findings from a cohort study in Japan","author":"Pham TM","year":"2008","journal-title":"Public Health Nutr"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/77.3.532"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70035-X"},{"key":"e_1_2_7_36_2","first-page":"130","article-title":"Association between nonsteroidal anti\u2010inflammatory drugs and prostate cancer occurrence","volume":"12","author":"Dasgupta K","year":"2006","journal-title":"Cancer J"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.4065\/77.3.219"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.01.031"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810696"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810084"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.4669"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.25811","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.25811","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.25811","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.25811","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.25811","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T15:56:35Z","timestamp":1692460595000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.25811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,26]]},"references-count":40,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,5,15]]}},"alternative-id":["10.1002\/ijc.25811"],"URL":"https:\/\/doi.org\/10.1002\/ijc.25811","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,26]]}}}