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All patients were below 40 years of age at diagnosis and\/or exhibited an overt family history. We employed genome\u2010wide copy number profiling using high\u2010resolution SNP arrays on germline DNA, which resulted in the identification of novel copy number variants (CNVs) in six patients (15%) encompassing, among others, the cadherin gene <jats:italic>CDH18<\/jats:italic>, the bone morphogenetic protein antagonist family gene <jats:italic>GREM1,<\/jats:italic> and the breakpoint cluster region gene <jats:italic>BCR<\/jats:italic>. In addition, two genomic deletions were encountered encompassing two microRNA genes, <jats:italic>hsa\u2010mir\u2010491<\/jats:italic>\/<jats:italic>KIAA1797<\/jats:italic> and <jats:italic>hsa\u2010mir\u2010646<\/jats:italic>\/<jats:italic>AK309218<\/jats:italic>. None of these CNVs has previously been reported in relation to CRC predisposition in humans, nor were they encountered in large control cohorts (&gt;1,600 unaffected individuals). Since several of these newly identified candidate genes may be functionally linked to CRC development, our results illustrate the potential of this approach for the identification of novel candidate genes involved in CRC predisposition.<\/jats:p>","DOI":"10.1002\/ijc.25821","type":"journal-article","created":{"date-parts":[[2010,12,2]],"date-time":"2010-12-02T14:54:27Z","timestamp":1291301667000},"page":"1635-1642","source":"Crossref","is-referenced-by-count":66,"title":["Identification of candidate predisposing copy number variants in familial and early\u2010onset colorectal cancer patients"],"prefix":"10.1002","volume":"129","author":[{"given":"Ramprasath","family":"Venkatachalam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eug\u00e8ne T.P.","family":"Verwiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eveline J.","family":"Kamping","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eveline","family":"Hoenselaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"G\u00f6rgens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans K.","family":"Schackert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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