{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T08:12:09Z","timestamp":1793779929045,"version":"4.6.1"},"reference-count":47,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2011,4,8]],"date-time":"2011-04-08T00:00:00Z","timestamp":1302220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cancer risks for a person who has inherited a <jats:italic>MUTYH<\/jats:italic> mutation from only one parent (monoallelic mutation carrier) are uncertain. Using the Colon Cancer Family Registry and Newfoundland Familial Colon Cancer Registry, we identified 2,179 first\u2010 and second\u2010degree relatives of 144 incident colorectal cancer (CRC) cases who were monoallelic or biallelic mutation carriers ascertained by sampling population complete cancer registries in the United States, Canada and Australia. Using Cox regression weighted to adjust for sampling on family history, we estimated that the country\u2010, age\u2010 and sex\u2010specific standardized incidence ratios (SIRs) for monoallelic mutation carriers, compared to the general population, were: 2.04 (95% confidence interval, CI 1.56\u20132.70; <jats:italic>p<\/jats:italic> &lt; 0.001) for CRC, 3.24 (95%CI 2.18\u20134.98; <jats:italic>p<\/jats:italic> &lt; 0.001) for gastric cancer, 3.09 (95%CI 1.07\u201312.25; <jats:italic>p<\/jats:italic> = 0.07) for liver cancer and 2.33 (95%CI 1.18\u20135.08; <jats:italic>p<\/jats:italic> = 0.02) for endometrial cancer. Age\u2010specific cumulative risks to age 70 years, estimated using the SIRs and US population incidences, were: for CRC, 6% (95%CI 5\u20138%) for men and 4% (95%CI 3\u20136%) for women; for gastric cancer, 2% (95%CI 1\u20133%) for men and 0.7% (95%CI 0.5\u20131%) for women; for liver cancer, 1% (95%CI 0.3\u20133%) for men and 0.3% (95%CI 0.1\u20131%) for women and for endometrial cancer, 4% (95%CI 2\u20138%). There was no evidence of increased risks for cancers of the brain, pancreas, kidney, lung, breast or prostate. Monoallelic <jats:italic>MUTYH<\/jats:italic> mutation carriers with a family history of CRC, such as those identified from screening multiple\u2010case CRC families, are at increased risk of colorectal, gastric, endometrial and possibly liver cancers.<\/jats:p>","DOI":"10.1002\/ijc.25870","type":"journal-article","created":{"date-parts":[[2010,12,17]],"date-time":"2010-12-17T16:19:48Z","timestamp":1292602788000},"page":"2256-2262","source":"Crossref","is-referenced-by-count":100,"title":["Cancer risks for monoallelic <i>MUTYH<\/i> mutation carriers with a family history of colorectal cancer"],"prefix":"10.1002","volume":"129","author":[{"given":"Aung Ko","family":"Win","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean P.","family":"Cleary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James 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