{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:57:44Z","timestamp":1791154664547,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,11,9]],"date-time":"2011-11-09T00:00:00Z","timestamp":1320796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2012,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>ADAM15, a member of the A Disintegrin And Metalloproteinase (ADAM) family, is a membrane protein containing an adhesion domain that binds to \u03b15\u03b21 integrin through a unique RGD domain. ADAM15, expressed by human normal colonocytes, is involved in epithelial wound healing and tissue remodeling in inflammatory bowel disease. The aims of our study were (<jats:italic>i<\/jats:italic>) to analyze ADAM15 expression in a series of colon carcinomas and paired normal mucosa and (<jats:italic>ii<\/jats:italic>) to integrate the spatial relationship of ADAM15 with its binding partners \u03b15\u03b21 integrin, a mesenchymal marker, as well as with other adhesion molecules, \u03b13\u03b21 integrin and E\u2010cadherin. A series of 94 colon carcinomas of the non other specified category were graded according to the World Health Organization classification. Immunohistochemistry was performed on frozen tissue sections using antibodies directed to ADAM15, \u03b15\u03b21 and \u03b13\u03b21 integrins, and E\u2010cadherin. ADAM15 was quantified at the mRNA level. Finally, promoter methylation of ADAM15 was examined as well as the microsatellite instability status (MSS\/MSI). Thirty\u2010six percent of colorectal carcinomas displayed a reduced expression of ADAM15 in cancer cells, confirmed at the mRNA level in most cases, without promoter methylation. ADAM15 down\u2010regulation was associated with histologically poorly differentiated carcinomas. In addition, it was associated with the acquisition of \u03b15\u03b21 by cancer cells and down\u2010regulation of \u03b13\u03b21 integrin and E\u2010cadherin. Finally this profile that includes characteristic of epithelial to mesenchymal transition is a late progression event of colon cancer with a poor prognosis.<\/jats:p>","DOI":"10.1002\/ijc.25891","type":"journal-article","created":{"date-parts":[[2010,12,28]],"date-time":"2010-12-28T14:32:05Z","timestamp":1293546725000},"page":"278-287","source":"Crossref","is-referenced-by-count":44,"title":["ADAM15 to \u03b15\u03b21 integrin switch in colon carcinoma cells: A late event in cancer progression associated with tumor dedifferentiation and poor prognosis"],"prefix":"10.1002","volume":"130","author":[{"given":"Claire","family":"Toquet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aude","family":"Colson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Jarry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Bezieau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Volteau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Boisseau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Merlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian L","family":"Laboisse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Fran\u00e7ois","family":"Mosnier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,11,9]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.7.2748"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1995.1152"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(98)80042-2"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M201792200"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2007.00434.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-1585"},{"key":"e_1_2_6_8_2","first-page":"17","article-title":"The disintegrin\u2010metalloproteinases ADAM9, ADAM12, and ADAM15 are upregulated in gastric cancer","volume":"26","author":"Carl\u2010McGrath S","year":"2005","journal-title":"Int J Oncol"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1593\/neo.05682"},{"key":"e_1_2_6_10_2","first-page":"793","article-title":"Increased expression of ADAM 9 and ADAM 15 mRNA in pancreatic cancer","volume":"27","author":"Yamada D","year":"2007","journal-title":"Anticancer Res"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-2432"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.9.4593"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.112.4.579"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00262.2004"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.07-8876rev"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700465"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63994-6"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63074-X"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.2353\/jmoldx.2008.070082"},{"key":"e_1_2_6_20_2","first-page":"314","volume-title":"World Health Organization Classification of Tumors. Pathology and genetics of tumors of the digestive system","author":"Hamilton SR","year":"2000"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.37070"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/27.4.109496"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22317"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2199-8-90"},{"key":"e_1_2_6_25_2","first-page":"235","article-title":"The CpG island searcher: a new WWW resource","volume":"3","author":"Takai D","year":"2003","journal-title":"In Silico Biol"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.052410099"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.3.342"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.48.2.143"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.09.055"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.02.031"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200210176"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.13.6161"},{"key":"e_1_2_6_33_2","first-page":"83","article-title":"Role of alpha 5 beta 1 integrin in determining malignant properties of colon carcinoma cells","volume":"8","author":"Gong J","year":"1997","journal-title":"Cell Growth Differ"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20989"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8536889"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-008-0464-1"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(00)00130-7"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199805)185:1<44::AID-PATH46>3.0.CO;2-A"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208423"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2164"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-0378"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.25891","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.25891","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T17:06:29Z","timestamp":1697475989000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.25891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,9]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,1,15]]}},"alternative-id":["10.1002\/ijc.25891"],"URL":"https:\/\/doi.org\/10.1002\/ijc.25891","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,9]]}}}