{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:41:26Z","timestamp":1780638086410,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,3,25]],"date-time":"2011-03-25T00:00:00Z","timestamp":1301011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Approximately 9% of gastric carcinomas worldwide are associated with Epstein\u2010Barr virus (EBV), making it the most frequent EBV\u2010associated malignancy. Pernicious anemia, a condition with chronic gastritis and achlorhydria, is strongly associated with gastric carcinoma. Both chronic inflammation and the lack of stomach acid may influence the likelihood of EBV infection of the neoplastic gastric epithelium, but the prevalence of EBV\u2010associated gastric carcinoma among patients with pernicious anemia is unknown. Therefore, we conducted a Danish nationwide case\u2013control study comparing gastric carcinoma patients with pernicious anemia (PA\u2010GC) with those without pernicious anemia (nonPA\u2010GC), frequency matched 1:2. Tumor tissues were reclassified by expert histopathologists blinded to pernicious anemia and EBV status. In total, 186 samples (55 PA\u2010GC and 131 nonPA\u2010GC) were identified. EBV\u2010associated gastric carcinoma (EBV\u2010GC) was more common among PA\u2010GC compared with nonPA\u2010GC, adjusted odds ratio (OR) = 2.53 (CI: 0.88; 7.14), <jats:italic>p<\/jats:italic> = 0.08, with further adjustment for lymphocytic infiltrate OR = 2.94 (0.99\u20138.67), <jats:italic>p<\/jats:italic> = 0.05. Gastric carcinomas with signet\u2010ring cell morphology were significantly less common in patients with PA\u2010GC compared with nonPA\u2010GC (OR = 0.05, CI 0.01; 0.24). Although these conditions are rare, we found suggestive evidence that EBV\u2010associated gastric carcinomas are more common among gastric carcinoma patients with pernicious anemia compared with those without.<\/jats:p>","DOI":"10.1002\/ijc.25925","type":"journal-article","created":{"date-parts":[[2011,1,10]],"date-time":"2011-01-10T17:10:01Z","timestamp":1294679401000},"page":"2756-2760","source":"Crossref","is-referenced-by-count":15,"title":["Epstein\u2010Barr virus\u2010associated gastric carcinoma among patients with pernicious anemia"],"prefix":"10.1002","volume":"129","author":[{"given":"Trine","family":"Boysen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeppe","family":"Friborg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrine","family":"Stribolt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Hamilton\u2010Dutoit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanne","family":"Goertz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Wohlfahrt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mads","family":"Melbye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,3,25]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"Epstein\u2010Barr virus and Kaposi's sarcoma herpes virus\/human herpes virus 8","author":"IARC Working Group","year":"1997"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605168"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2007.00674.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.05.001"},{"key":"e_1_2_6_6_2","first-page":"947","volume-title":"Human herpes viruses\u2014biology, therapy, and immunoprophylaxis","author":"Hjalgrim H","year":"2008"},{"key":"e_1_2_6_7_2","first-page":"769","article-title":"Epstein\u2010Barr virus\u2010associated gastric adenocarcinoma","volume":"140","author":"Shibata D","year":"1992","journal-title":"Am J Pathol"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.19.9131"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910600513"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/08916930410001705439"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199711133372007"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.7.938"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1996.195"},{"key":"e_1_2_6_14_2","first-page":"263","article-title":"The Danish National Hospital Register. 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