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Subjects comprised asymptomatic, middle\u2010aged, male Japanese factory workers who participated in an annual health check\u2010up program, including cancer screening with colonoscopy. We selected 239 colorectal adenoma cases based on histological evaluation and 239 age\u2010matched adenoma\u2010free controls, and evaluated colorectal adenoma risk according to stage of <jats:italic>H. pylori<\/jats:italic>\u2010related chronic gastritis as determined by serum tests for <jats:italic>H. pylori<\/jats:italic> antibody titer and pepsinogen. Subjects with colorectal adenoma were more likely to be smokers and have hypercholesterolemia. <jats:italic>H. pylori<\/jats:italic> infection was a risk factor for adenoma as a whole (crude odds ratio [OR]: 2.26, 95% confidence interval [CI]: 1.44\u20133.55). Analysis of distal adenoma cases showed that adenoma risk was significantly increased in the presence of <jats:italic>H. pylori<\/jats:italic> infection, but there was no further increase in risk with CAG. In contrast, proximal adenoma risk increased stepwise with the presence and progression of <jats:italic>H. pylori<\/jats:italic>\u2010related chronic gastritis and showed a maximal and significant increase with CAG (crude OR: 4.51, 95% CI: 1.43\u201314.2). Subjects with more extensive and severe gastritis showed still higher risk not only for proximal but also for distal adenoma. <jats:italic>H. pylori<\/jats:italic>\u2010related chronic gastritis is likely to be involved in the development of colorectal neoplasms, and its progression appears to increase the risk, particularly for proximal adenomas. Knowing the <jats:italic>H. pylori<\/jats:italic>\u2010related chronic gastritis stage will probably be useful for evaluation of risk for colorectal neoplasia.<\/jats:p>","DOI":"10.1002\/ijc.25931","type":"journal-article","created":{"date-parts":[[2011,1,10]],"date-time":"2011-01-10T17:10:05Z","timestamp":1294679405000},"page":"2704-2711","source":"Crossref","is-referenced-by-count":50,"title":["Elevated risk of colorectal adenoma with <i>Helicobacter pylori<\/i>\u2010related chronic gastritis: A population\u2010based case\u2010control study"],"prefix":"10.1002","volume":"129","author":[{"given":"Izumi","family":"Inoue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chizu","family":"Mukoubayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tohru","family":"Niwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisanobu","family":"Deguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shotaro","family":"Enomoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Maekita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikitaka","family":"Iguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimihiko","family":"Yanaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Tamai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Arii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Oka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiro","family":"Fujishiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Takeshita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Iwane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Mohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Ichinose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,3,8]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.3.378"},{"key":"e_1_2_6_3_2","first-page":"6735","article-title":"Human gastric carcinogenesis: a multistep and multifactorial process\u2014first American cancer society award lecture on cancer epidemiology and prevention","volume":"52","author":"Correa P","year":"1992","journal-title":"Cancer Res"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11680"},{"key":"e_1_2_6_5_2","first-page":"683","article-title":"Role of Helicobacter pylori infection in extragastroduodenal disorders: introductory remarks","volume":"50","author":"Konturek SJ","year":"1999","journal-title":"J Physiol Pharmacol"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000199848"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-1871-6_19"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21027"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i16.2588"},{"key":"e_1_2_6_10_2","volume-title":"Age\u2010adjusted death rates by prefecture. 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