{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:34:37Z","timestamp":1790854477306,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,4,13]],"date-time":"2011-04-13T00:00:00Z","timestamp":1302652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The impact of a human papillomavirus (HPV) vaccine on development of cervical intraepithelial neoplasia grade 2\u20103 or adenocarcinoma <jats:italic>in situ<\/jats:italic> (CIN2\u20103\/AIS) in women with ongoing HPV16 or 18 infections prevaccination is reported. Seventeen thousand six\u2010hundred and twenty\u2010two women aged 16\u201326 were enrolled in 1 of 2 randomized, placebo\u2010controlled, efficacy trials (Protocols 013 and 015). Vaccine or placebo was given at day 1, month 2 and 6. Women were tested for HPV6\/11\/16\/18 DNA and antibodies at day 1. We focus on the subset of women who were seropositive and DNA positive to HPV16 or HPV18 prevaccination. Incidence is expressed as the number of women with an endpoint per 100 person\u2010years\u2010at\u2010risk. In total, 419 vaccine and 446 placebo recipients were both seropositive and DNA positive to HPV16 or HPV18 prevaccination and had at least one follow\u2010up visit. In Protocol 013, the incidence of HPV16\/18\u2010related CIN2\u20103\/AIS among these women was 10.9 in the vaccine arm and 7.0 in the placebo arm (vaccine efficacy = \u221254.9; 95% CI: \u2212181.7, 13.0). In Protocol 015, the incidence of HPV16\/18\u2010related CIN2\u20103\/AIS was 5.5 in the vaccine arm and 6.2 in the placebo arm (vaccine efficacy = 12.2%; 95% CI: \u221229.8, 40.9). These data suggest HPV vaccination neither reduces nor enhances progression to HPV16\/18\u2010related high grade cervical lesions, and cervical cytology screening and corresponding management should continue as per local recommendations. Ultimately, population\u2010based surveillance of vaccinated individuals beyond these clinical trials will be required to further address questions regarding the impact of vaccination in women exposed to vaccine HPV types before vaccination.<\/jats:p>","DOI":"10.1002\/ijc.25940","type":"journal-article","created":{"date-parts":[[2011,1,20]],"date-time":"2011-01-20T16:12:57Z","timestamp":1295539977000},"page":"2632-2642","source":"Crossref","is-referenced-by-count":51,"title":["Impact of an HPV6\/11\/16\/18 L1 virus\u2010like particle vaccine on progression to cervical intraepithelial neoplasia in seropositive women with HPV16\/18 infection"],"prefix":"10.1002","volume":"129","author":[{"given":"Richard M.","family":"Haupt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosette M.","family":"Wheeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darron R.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne M.","family":"Garland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daron G.","family":"Ferris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorma A.","family":"Paavonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti O.","family":"Lehtinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Steben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmar A.","family":"Joura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine E. 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