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Four galectins: galectin \u22121, \u22123, \u22124 and \u22128 are expressed in the human colon and rectum and their expressions show significant changes during colorectal cancer development and metastasis. These changes in galectin expression correlate with alterations in cancer cell growth, apoptosis, cell\u2013cell and cell\u2013matrix interactions and angiogenesis. This review summaries current knowledge of the expression and roles of these galectins in the progression of human colorectal cancer and discusses the relevance of galectins and their ligands as potential therapeutic targets for cancer treatment.<\/jats:p>","DOI":"10.1002\/ijc.25945","type":"journal-article","created":{"date-parts":[[2011,1,20]],"date-time":"2011-01-20T16:13:36Z","timestamp":1295540016000},"page":"1-8","source":"Crossref","is-referenced-by-count":91,"title":["The role of galectins in colorectal cancer progression"],"prefix":"10.1002","volume":"129","author":[{"given":"Hannah","family":"Barrow","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan 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