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By using oligonucleotide arrays, we now demonstrate that knockdown of WASF3 leads to the upregulation of the <jats:italic>KISS1<\/jats:italic> metastasis suppressor gene with concomitant reduced invasion and loss of matrix metalloproteinases (MMP)\u20109 activity. Using a luciferase reporter, KISS1 transcription is significantly increased in the absence of WASF3. Knockdown of <jats:italic>KISS1<\/jats:italic> in WASF3\u2010silenced cells resulted in the recovery of the invasion phenotype. <jats:italic>WASF3<\/jats:italic> knockdown also resulted in elevated I\u03baB\u03b1 levels in the cytoplasm and reduced levels of nuclear factor\u2010kappa\u2010B (NF\u2010\u03baB) p65\/50 subunits in the nucleus. Tumor necrosis factor\u2010alpha (TNF\u2010\u03b1) has been associated with cell invasion through induction of MMP\u20109 production <jats:italic>via<\/jats:italic> KISS1 regulation of the NF\u2010\u03baB pathway. When WASF3 knockdown cells are treated with TNF\u2010\u03b1, no effect is seen on invasion or nuclear translocation of NF\u2010\u03baB. Thus, coordinated expression patterns of the WASF3 metastasis promoter gene and the KISS1 metastasis suppressor gene appear to exert their influence through inhibition of NF\u2010\u03baB signaling, which in turn regulates MMP\u20109 production facilitating invasion.<\/jats:p>","DOI":"10.1002\/ijc.25964","type":"journal-article","created":{"date-parts":[[2011,2,3]],"date-time":"2011-02-03T15:05:56Z","timestamp":1296745556000},"page":"2825-2835","source":"Crossref","is-referenced-by-count":54,"title":["Functional interrelationship between the WASF3 and KISS1 metastasis\u2010associated genes in breast cancer cells"],"prefix":"10.1002","volume":"129","author":[{"given":"Yong","family":"Teng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John 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