{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T05:17:28Z","timestamp":1784265448688,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,5,5]],"date-time":"2011-05-05T00:00:00Z","timestamp":1304553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2012,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cervical cancer (CxCa) is caused by persistent human papillomavirus (HPV) infection; genetic predisposition is also suspected to play a role. Our study is a targeted candidate gene follow\u2010up based on: (<jats:italic>i<\/jats:italic>) strong clinical evidence demonstrating that mutations in the <jats:italic>TMC6<\/jats:italic> and <jats:italic>TMC8<\/jats:italic> (<jats:italic>EVER1<\/jats:italic> and <jats:italic>EVER2<\/jats:italic>) genes associate with the HPV\u2010associated disease epidermodysplasia verruciformis (EV) and (<jats:italic>ii<\/jats:italic>) recent epidemiological data suggesting a genetic susceptibility conferred by polymorphisms in such genes for skin and CxCa. Clarifying the association of the <jats:italic>TMC6\/8<\/jats:italic> genes with risk of CxCa will help in understanding why some HPV\u2010infected women develop persistent infection, cervical lesions and eventually cancer while others do not. Twenty\u2010two single nucleotide polymorphisms (SNPs) harboring the <jats:italic>TMC6\/8<\/jats:italic> genes were genotyped in 2,989 cases with cervical intraepithelial neoplasia grade III or invasive CxCa and 2,281 controls from the Swedish population. Association was evaluated in logistic regression models. Two SNPs displayed association with cervical disease: rs2290907 [odds ratio (OR)<jats:sub>GG<jats:italic>vs<\/jats:italic>AA<\/jats:sub> = 0.6, 95% confidence interval (95% CI): 0.3\u20130.9, <jats:italic>p<\/jats:italic> = 0.02)] and rs16970849 (OR<jats:sub>AG<jats:italic>vs<\/jats:italic>GG<\/jats:sub> = 0.8, 95% CI: 0.66\u20130.98, <jats:italic>p<\/jats:italic> = 0.03). The present data support the involvement of the <jats:italic>TMC6\/8<\/jats:italic> region in CxCa susceptibility but further analyses are needed to replicate our findings, fully characterize the region and understand the function of the genetic variants involved.<\/jats:p>","DOI":"10.1002\/ijc.26016","type":"journal-article","created":{"date-parts":[[2011,3,8]],"date-time":"2011-03-08T15:45:02Z","timestamp":1299599102000},"page":"349-355","source":"Crossref","is-referenced-by-count":34,"title":["Contribution of <i>TMC6<\/i> and <i>TMC8<\/i> (<i>EVER1<\/i> and <i>EVER2<\/i>) variants to cervical cancer susceptibility"],"prefix":"10.1002","volume":"130","author":[{"given":"Felipe A.","family":"Castro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma 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