{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T13:23:43Z","timestamp":1784294623114,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,5,5]],"date-time":"2011-05-05T00:00:00Z","timestamp":1304553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>High\u2010risk human papillomavirus (hrHPV) testing has a higher sensitivity but lower specificity than cytology for detection of high\u2010grade intraepithelial neoplasia (CIN). To avoid over\u2010referral to colposcopy and overtreatment, hrHPV\u2010positive women require triage testing and\/or followup. A total of 25,658 women (30\u201360 years) enrolled in a population\u2010based cohort study had an adequate baseline Pap smear and hrHPV test. The end\u2010point was cumulative two\u2010year risk of CIN grade 3 or worse (CIN3+). In a post\u2010hoc analysis, fourteen triage\/followup strategies for hrHPV\u2010positive women (<jats:italic>n<\/jats:italic> = 1,303) were evaluated for colposcopy referral rate, positive (PPV) and negative predictive value (NPV). Five strategies involved triage testing without a repeat test and nine strategies involved triage testing followed by one repeat testing. The tests were cytology, hrHPV, HPV16\/18 genotyping and HPV16\/18\/31\/33\/45 genotyping. Results were adjusted for women in the cohort study who did not attend repeat testing. Of the strategies without repeat testing, combined cytology and HPV16\/18\/31\/33\/45 genotyping gave the highest NPV of 98.9% (95%CI 97.6\u201399.5%). The corresponding colposcopy referral rate was 58.1% (95%CI 55.4\u201360.8%). Eight of the nine strategies with retesting had an estimated NPV of at least 98%. Of those, cytology triage followed by cytology at 12 months had a markedly lower colposcopy referral rate of 33.4% (95%CI 30.2\u201336.7%) than the other strategies. The NPV of the latter strategy was 99.3% (95%CI 98.1\u201399.8%). Triage hrHPV\u2010positive women with cytology, followed by repeat cytology testing yielded a high NPV and modest colposcopy referral rate and appear to be the most feasible management strategy.<\/jats:p>","DOI":"10.1002\/ijc.26056","type":"journal-article","created":{"date-parts":[[2011,3,11]],"date-time":"2011-03-11T16:17:17Z","timestamp":1299860237000},"page":"602-610","source":"Crossref","is-referenced-by-count":178,"title":["Evaluation of 14 triage strategies for HPV DNA\u2010positive women in population\u2010based cervical screening"],"prefix":"10.1002","volume":"130","author":[{"given":"Dorien C.","family":"Rijkaart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Berkhof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Folkert J.","family":"van 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