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In our study, we investigated the role of Thanatos\u2010associated protein 11 (THAP11), which inhibits c\u2010Myc transcription, in CML cell lines and in hematopoietic progenitor cells derived from CML patients. The induction of THAP11 expression by Abl kinase inhibitors in CML cell lines and in CML\u2010derived hematopoietic progenitor cells resulted in the suppression of c\u2010Myc. In addition, over\u2010expression of THAP11 inhibited CML cell proliferation. In colony forming cells derived from CML\u2010aldehyde dehydrogenase (ALDH)<jats:sup>hi<\/jats:sup>\/CD34<jats:sup>+<\/jats:sup> cells, treatment with Abl kinase inhibitors and siRNA depletion of Bcr\u2010Abl induced THAP11 expression and reduced c\u2010Myc expression, resulting in inhibited colony formation. Moreover, overexpression of THAP11 significantly decreased the colony numbers, and also inhibited the expression of c\u2010myc target genes such as Cyclin D1, ODC and induced the expression of p21<jats:italic><jats:sup>Cip1<\/jats:sup><\/jats:italic>. The depletion of THAP11 inhibited JAK2 or STAT5 inactivation\u2010mediated c\u2010Myc reduction in ALDH<jats:sup>hi<\/jats:sup>\/CD34<jats:sup>+<\/jats:sup> CML cells. Thus, the induced THAP11 might be one of transcriptional regulators of c\u2010Myc expression in CML cell. Therefore, the induction of THAP11 has a potential possibility as a target for the inhibition of CML cell proliferation.<\/jats:p>","DOI":"10.1002\/ijc.26065","type":"journal-article","created":{"date-parts":[[2011,3,11]],"date-time":"2011-03-11T16:18:35Z","timestamp":1299860315000},"page":"1046-1059","source":"Crossref","is-referenced-by-count":20,"title":["Down\u2010regulation of Thanatos\u2010associated protein 11 by BCR\u2010ABL promotes CML cell proliferation through c\u2010Myc 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