{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:44:27Z","timestamp":1786977867000,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,5,30]],"date-time":"2011-05-30T00:00:00Z","timestamp":1306713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cigarette smoke (CS) plays a dominant role in the epidemiology of human cancer. However, it is difficult to reproduce its carcinogenicity in laboratory animals. Recently, we showed that CS becomes a potent carcinogen in mice when exposure starts soon after birth. In our study, we comparatively evaluated the carcinogenic response to mainstream CS in mice at different ages. Neonatal mice were exposed daily for 4 months to CS, starting within 12 hr after birth, and sacrificed at 8 months. Adult mice were exposed for the same time period (3\u20137 months) and sacrificed at 11 months. Other mice were exposed transplacentally or both transplacentally and early in life. A total of 351 neonatal mice and 80 adult Swiss H mice were used. With varying intensity depending on age, CS induced pulmonary emphysema, bronchial and alveolar epithelial hyperplasia, blood vessel proliferation and hemangiomas and microadenomas in lung as well as parenchymal degeneration of liver. Histopathological alterations of kidney were only observed in mice exposed to CS early in life. Lung adenomas and malignant tumors of various histopathological nature were detected in neonatally exposed mice but not in adults. Transplacental CS induced the formation of lung adenomas in the offspring 8 months after birth. Previous exposure during pregnancy attenuated CS\u2010related alveolar epithelial hyperplasia induced after birth. In conclusion, the carcinogenic response to CS varies depending on the developmental stage. The early postnatal life and the prenatal life are particularly at risk for the later development of CS\u2010related tumors.<\/jats:p>","DOI":"10.1002\/ijc.26103","type":"journal-article","created":{"date-parts":[[2011,4,11]],"date-time":"2011-04-11T09:13:54Z","timestamp":1302513234000},"page":"1001-1010","source":"Crossref","is-referenced-by-count":30,"title":["Differential carcinogenicity of cigarette smoke in mice exposed either transplacentally, early in life or in adulthood"],"prefix":"10.1002","volume":"130","author":[{"given":"Roumen","family":"Balansky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gancho","family":"Ganchev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marietta","family":"Iltcheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manasi","family":"Nikolov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vernon E.","family":"Steele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio","family":"De Flora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,5,30]]},"reference":[{"key":"e_1_2_6_2_2","series-title":"Tobacco smoke and involuntary smoking. IARC monographs on the evaluation of the carcinogenic risks to humans","author":"International Agency for Research on Cancer","year":"2004"},{"key":"e_1_2_6_3_2","first-page":"43","volume-title":"Reducing the health consequences of smoking, 25 years of progress. Office on Smoking and Health","author":"US Department of Health and Human Services","year":"1989"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.14.1194"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01636815"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/08958370290084746"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgi148"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(02)00340-8"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-3882"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.04.011"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-121384"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2005.05.005"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/18.3.575"},{"key":"e_1_2_6_14_2","first-page":"607","article-title":"Pilot studies evaluating the lung tumor yield in cigarette smoke\u2010exposed mice","volume":"18","author":"D'Agostini F","year":"2001","journal-title":"Int J Oncol"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfh175"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/08958370590922544"},{"key":"e_1_2_6_17_2","first-page":"793","article-title":"Molecular alterations and lung tumors in p53 mutant mice exposed to cigarette smoke","volume":"63","author":"De Flora S","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208390"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/18.11.2035"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2010.05.005"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfh203"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgi150"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2003.05.004"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgm122"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgp128"},{"key":"e_1_2_6_26_2","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1002\/ijc.24942","article-title":"Prevention of cigarette smoke\u2010induced lung cancer in mice by budesonide, phenethyl isothiocyanate, and N\u2010acetylcysteine","volume":"126","author":"Balansky R","year":"2009","journal-title":"Int J Cancer"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23836"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60970-7"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1218(87)90109-1"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(97)00193-7"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2004.02.015"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdh051"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2007.11.004"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00126.2006"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00054.2006"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2003.11.008"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2797(88)90020-8"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2006.10.001"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2005.10.012"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-199512000-00005"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1080\/01902140150216774"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/14.8.1545"},{"key":"e_1_2_6_43_2","first-page":"379","article-title":"Tumor development in lung of ddY mice following transplacental exposure to 1\u2010ethyl\u20101\u2010nitrosourea","volume":"70","author":"Umezawa I","year":"1979","journal-title":"Gann"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(78)80011-1"},{"key":"e_1_2_6_45_2","first-page":"811","article-title":"Transplacental and neonatal carcinogenesis by 1\u2010butyl\u20101\u2010nitrosourethan in the ACI\/N rat","volume":"71","author":"Maekawa A","year":"1980","journal-title":"Gann"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1218(89)90056-6"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2003.07.018"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0967fje"},{"key":"e_1_2_6_49_2","first-page":"64","article-title":"Blastomogenesis induced by the combined tranplacental and postnatal exposure to N\u2010nitrosodiethylamine (NDEA) in mice","volume":"17","author":"Likhacev AJ","year":"1971","journal-title":"Vopr Onkol"},{"key":"e_1_2_6_50_2","first-page":"155","volume-title":"Transplacental and multigenerational carcinogenesis","author":"Anderson LM","year":"1983"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-2797(01)00265-4"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.26103","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.26103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T21:53:55Z","timestamp":1712354035000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.26103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,30]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1002\/ijc.26103"],"URL":"https:\/\/doi.org\/10.1002\/ijc.26103","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,30]]}}}