{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:17:37Z","timestamp":1791181057763,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,6,18]],"date-time":"2011-06-18T00:00:00Z","timestamp":1308355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Near infrared fluorescence\u2010guidance can be used for the detection of small cancer metastases and can aid in the endoscopic management of cancer. Indocyanine green (ICG) is a Food and Drug Administration (FDA)\u2010approved fluorescence agent. Through non\u2010specific interactions with serum proteins, ICG achieves enhanced permeability and retention (EPR) effects. Yet, ICG demonstrates rapid clearance from the circulation. Therefore, ICG may be an ideal contrast agent for real\u2010time fluorescence imaging of tumors. To evaluate the usefulness of real\u2010time dual fluorescence and white light endoscopic optical imaging to detect tumor implants using the contrast agent ICG, fluorescence\u2010guided laparoscopic procedures were performed in mouse models of peritoneally disseminated ovarian cancers. Animals were administered intravenous ICG or a control contrast agent, IR800\u2010conjugated to albumin. The ability to detect small ovarian cancer implants was then compared. Using the dual view microendoscope, ICG clearly enabled visualization of peritoneal ovarian cancer metastatic nodules derived from SHIN3 and OVCAR5 cells at 6 and 24 hr after injection with significantly higher tumor\u2010to\u2010background ratio than the control agent, IR800\u2010albumin (<jats:italic>p<\/jats:italic> &lt; 0.001). In conclusion, ICG has the desirable properties of having both EPR effects and rapid clearance for the real\u2010time endoscopic detection of tiny ovarian cancer peritoneal implants compared to a control macromolecular agent with theoretically better EPR effects but longer circulatory retention. Given that ICG is already FDA\u2010approved and has a long track record of human use, this method could be easily translated to the clinic as a robust tool for fluorescence\u2010guided endoscopic procedures for the management and treatment of cancer.<\/jats:p>","DOI":"10.1002\/ijc.26113","type":"journal-article","created":{"date-parts":[[2011,4,5]],"date-time":"2011-04-05T17:28:43Z","timestamp":1302024523000},"page":"1671-1677","source":"Crossref","is-referenced-by-count":102,"title":["Near infrared fluorescence\u2010guided real\u2010time endoscopic detection of peritoneal ovarian cancer nodules using intravenously injected indocyanine green"],"prefix":"10.1002","volume":"129","author":[{"given":"Nobuyuki","family":"Kosaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Mitsunaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle 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