{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:21:50Z","timestamp":1790907710223,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,5,30]],"date-time":"2011-05-30T00:00:00Z","timestamp":1306713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We evaluated the effect of offering brush\u2010based vaginal self\u2010sampling for high\u2010risk human papillomavirus (hrHPV) testing to non\u2010attendees of the cervical screening program on response rate, compliance to follow\u2010up and cervical intraepithelial neoplasia grade 2 or 3 (CIN2+\/CIN3+) yield. In addition, concordance of hrHPV test results between physician\u2010taken cervical scrapes and vaginal self\u2010samples was determined. A total of 26,409 nonattending women were randomly assigned to receive a vaginal brush device for hrHPV testing by Hybrid Capture\u20102\u00ae method (<jats:italic>i.e.,<\/jats:italic> self\u2010sampling group, <jats:italic>n<\/jats:italic> = 26,145) or a reinvitation for regular cytology\u2010based screening (<jats:italic>i.e.,<\/jats:italic> recall control group, <jats:italic>n<\/jats:italic> = 264). hrHPV\u2010positive self\u2010sampling responders were invited for a physician\u2010taken scrape for cytology and blinded hrHPV testing. If cytology was abnormal, women were referred for colposcopy. Response rate in the self\u2010sampling group was significantly increased compared to the recall control group (30.8% <jats:italic>versus<\/jats:italic> 6.5%; <jats:italic>p<\/jats:italic> &lt; 0.001). The concordance rate between hrHPV detection in self\u2010samples and corresponding physician\u2010taken cervical scrape samples was 68.8%. Amongst women with CIN3+ and CIN2+, the concordance rates in hrHPV positivity between both samples were 95.5% and 93.8%, respectively. Adherence at baseline to cytology triage of hrHPV\u2010positive self\u2010sampling women (89.1%) and colposcopy referral of those with abnormal cytology (95.8%) was high. The CIN2+\/CIN3+\/carcinoma yields were 1.5%, 1.0% and 0.1%, respectively, in self\u2010sampling responders. In conclusion, offering hrHPV testing on self\u2010sampled vaginal material with a brush device to non\u2010attendees significantly increases the attendance to the regular screening program, yields hrHPV test results that are in very good concordance with those of physician\u2010taken scrapes in women with CIN2+\/CIN3+, and is effective in detecting CIN2+\/CIN3+.<\/jats:p>","DOI":"10.1002\/ijc.26128","type":"journal-article","created":{"date-parts":[[2011,4,11]],"date-time":"2011-04-11T13:14:23Z","timestamp":1302527663000},"page":"1128-1135","source":"Crossref","is-referenced-by-count":110,"title":["Experience with high\u2010risk human papillomavirus testing on vaginal brush\u2010based self\u2010samples of non\u2010attendees of the cervical screening program"],"prefix":"10.1002","volume":"130","author":[{"given":"Murat","family":"G\u00f6k","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Folkert J.","family":"van Kemenade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dani\u00eblle A.M.","family":"Heideman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Berkhof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Rozendaal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan W.M.","family":"Spruyt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen A.M.","family":"Beli\u00ebn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Babovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.F.","family":"Snijders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris J.L.M.","family":"Meijer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,5,30]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22167"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22484"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22114"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.1.108"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.1.81"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1998.5135"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c1040"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000326965"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24891"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02078-05"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2003.011841"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.85.6.791"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2004.011858"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2007.01.023"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21835"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02440-05"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24010"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.26128","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.26128","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T13:11:27Z","timestamp":1697461887000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.26128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,30]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1002\/ijc.26128"],"URL":"https:\/\/doi.org\/10.1002\/ijc.26128","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,30]]}}}