{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T09:02:16Z","timestamp":1789462936248,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,7,21]],"date-time":"2011-07-21T00:00:00Z","timestamp":1311206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2012,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lignans are a group of estrogenic compounds present in plants. Several epidemiological studies proposed that lignans may protect against breast cancer by exerting anticarcinogenic activity. Levels of enterolactone were determined in serum samples of 1,250 cases and 2,164 controls from a large population\u2010based case\u2013control study. We assessed the association between serum enterolactone and postmenopausal breast cancer risk using conditional logistic regression accounting for potential risk and confounding factors. Fractional polynomials were used to determine the function that best fitted the data. Moreover, we assessed heterogeneity by estrogen\/progesterone\/herceptin (ER\/PR\/HER2) status of the tumor. Additionally, a meta\u2010analysis with seven further studies addressing enterolactone concentrations and breast cancer risk was performed. Postmenopausal breast cancer risk decreased with increasing serum enterolactone levels [highest compared to lowest quintile: [odds ratio = 0.65; 95% confidence interval (CI) 0.52\u20130.83, <jats:italic>p<\/jats:italic><jats:sub>trend<\/jats:sub> = &lt;0.0001]. A significant inverse association for ER+\/PR+ as well as ER\u2212\/PR\u2212 tumors was observed, with a significantly stronger association for ER\u2212\/PR\u2212 tumors (<jats:italic>p<\/jats:italic><jats:sub>heterogeneity<\/jats:sub> = 0.03). The association for ER\u2212\/PR\u2212 tumors did not differ by expression of HER2 (<jats:italic>p<\/jats:italic><jats:sub>heterogeneity<\/jats:sub> = 0.3). The meta\u2010analysis yielded a significant reduced pooled risk estimate of: 0.66; 95% CI: 0.55\u20130.77) comparing the highest to the lowest quantiles of enterolactone levels. We found strong evidence for a significant inverse association between serum enterolactone and postmenopausal breast cancer risk, which was stronger for ER\u2212PR\u2212 than for ER+PR+ tumors but not differential by further expression of HER2. The overall evidence together with other studies supports an inverse association between higher serum enterolactone levels and postmenopausal breast cancer risk.<\/jats:p>","DOI":"10.1002\/ijc.26157","type":"journal-article","created":{"date-parts":[[2011,5,4]],"date-time":"2011-05-04T17:48:26Z","timestamp":1304531306000},"page":"1401-1410","source":"Crossref","is-referenced-by-count":46,"title":["Serum enterolactone and postmenopausal breast cancer risk by estrogen, progesterone and herceptin 2 receptor status"],"prefix":"10.1002","volume":"130","author":[{"given":"Aida Karina","family":"Zaineddin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Vrieling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Buck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susen","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Linseisen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Flesch\u2010Janys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Kaaks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Chang\u2010Claude","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,7,21]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015786030864"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djg015"},{"key":"e_1_2_6_4_2","first-page":"339","article-title":"Serum enterolactone and risk of breast cancer: a case\u2010control study in eastern Finland","volume":"10","author":"Pietinen P","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.6.1596"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2005.03.006"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0960-0760(93)90022-O"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.10538"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021381101632"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-200212000-00002"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.3109\/07853899709113696"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-2863(00)00085-1"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114500002075"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19980007"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/154.5.434"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20119"},{"key":"e_1_2_6_17_2","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1093\/ajcn\/79.2.282","article-title":"Dietary phytoestrogens and breast cancer risk","volume":"79","author":"Keinan\u2010Boker L","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_6_18_2","first-page":"223","article-title":"Urinary phytoestrogens and postmenopausal breast cancer risk","volume":"10","author":"den T","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/155.5.472"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.0244"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)01339-1"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601893"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.28573"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.05.019"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23655"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1998.2886"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-128X(00)00089-1"},{"key":"e_1_2_6_28_2","first-page":"138","article-title":"[Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER\u2010ICA) in breast cancer tissue]","volume":"8","author":"Remmele W","year":"1987","journal-title":"Pathologe"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(11)81095-2"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/28.5.964"},{"key":"e_1_2_6_31_2","volume-title":"R Development Core Team. R: a language and environment for statistical computing","year":"2008"},{"key":"e_1_2_6_32_2","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1158\/1055-9965.2084.13.12","article-title":"Plasma enterolactone and breast cancer incidence by estrogen receptor status","volume":"13","author":"Olsen A","year":"2004","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_6_33_2","first-page":"815","article-title":"Urinary excretion of phytoestrogens and risk of breast cancer among Chinese women in Shanghai","volume":"11","author":"Dai Q","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11519"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601517"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0162"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/73.6.1094"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408360701612942"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.cej.0000197449.56862.75"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-002-0373-3"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.3945\/jn.108.101691"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.7.2223"},{"key":"e_1_2_6_43_2","first-page":"897","article-title":"A review of the clinical effects of phytoestrogens","volume":"87","author":"Knight DC","year":"1996","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1186\/bcr1995"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djk096"},{"key":"e_1_2_6_46_2","first-page":"885","article-title":"Reliability of serum measurements of lignans and isoflavonoid phytoestrogens over a two\u2010year period","volume":"7","author":"Zeleniuch\u2010Jacquotte A","year":"1998","journal-title":"Cancer Epidemiol Biomarkers Prev"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.26157","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.26157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T15:30:11Z","timestamp":1724859011000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.26157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,21]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,3,15]]}},"alternative-id":["10.1002\/ijc.26157"],"URL":"https:\/\/doi.org\/10.1002\/ijc.26157","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,21]]}}}