{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T17:47:41Z","timestamp":1787852861781,"version":"build-2784847793"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,8,16]],"date-time":"2011-08-16T00:00:00Z","timestamp":1313452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2012,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Self\u2010collected vaginal specimens tested for high\u2010risk human papillomavirus (HR\u2010HPV) have been shown to be less sensitive for the detection of cervical intraepithelial neoplasia or cancer (\u2265CIN 3) than physician\u2010collected endocervical specimens. To increase the sensitivity of self\u2010collected specimens, we studied a self\u2010sampling device designed to obtain a larger specimen from the upper vagina (POI\/NIH self\u2010sampler) and a more sensitive polymerase chain reaction (PCR)\u2010based HR\u2010HPV assay. Women (10,000) were screened with cervical cytology and HR\u2010HPV testing of vaginal self\u2010collected and endocervical physician\u2010collected specimens. Women were randomly assigned to use either a novel self\u2010collection device (POI\/NIH self\u2010sampler) or conical\u2010shaped brush (Qiagen). The self\u2010collected and clinician\u2010collected specimens were assayed by Cervista (Hologic) and the research only PCR\u2010based matrix\u2010assisted laser desorption\/ionization time\u2010of\u2010flight (MALDI\u2010TOF). Women with any abnormal screening test underwent colposcopy and biopsy. Women (8,556), mean age of 38.9, had complete data; 1.6% had \u2265 CIN 3. For either HR\u2010HPV assay, the sensitivity was similar for the two self\u2010collection devices. Tested with Cervista, the sensitivity for \u2265CIN 3 of self\u2010collected specimens was 70.9% and for endocervical specimens was 95.0% (<jats:italic>p<\/jats:italic> = 0.0001). Tested with MALDI\u2010TOF, the sensitivity for \u2265CIN 3 of self\u2010collected specimens was 94.3% and for endocervical specimens was also 94.3% (<jats:italic>p<\/jats:italic> = 1.0). A self\u2010collected sample using a PCR\u2010based assay with the capability of very high throughput has similar sensitivity as a direct endocervical specimen obtained by a physician. Large population\u2010based screening \u201cevents\u201d in low\u2010resource settings could be achieved by promoting self\u2010collection and centralized high\u2010throughput, low\u2010cost testing by PCR\u2010based MALDI\u2010TOF.<\/jats:p>","DOI":"10.1002\/ijc.26202","type":"journal-article","created":{"date-parts":[[2011,5,31]],"date-time":"2011-05-31T13:22:35Z","timestamp":1306848155000},"page":"1855-1860","source":"Crossref","is-referenced-by-count":86,"title":["Improved sensitivity of vaginal self\u2010collection and high\u2010risk human papillomavirus testing"],"prefix":"10.1002","volume":"130","author":[{"given":"Jerome L.","family":"Belinson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne E.","family":"Belinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinfeng","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Pretorius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip E.","family":"Castle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,8,16]]},"reference":[{"key":"e_1_2_5_2_2","unstructured":"IARC. 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