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We recently demonstrated that highly peptide\u2010 and HLA\u2010specific T cells can readily be generated against allogeneic HLA\u2010A*02:01 in complex with a peptide from the B cell\u2010restricted protein CD20. Here, we show that such CD20\u2010specific T cells can easily be induced from na\u00efve precursors in cord blood, demonstrating that they do not represent cross\u2010reactive memory cells. The cells displayed high avidity and mediated potent cytotoxic effects on cells from patients with the CD20<jats:sup>pos<\/jats:sup> B cell malignancies follicular lymphoma (FL) and acute lymphoblastic leukemia (ALL). However, the cytotoxicity was consistently lower for cells from two of the ALL patients. The ALL cells that were less efficiently killed did not display lower surface expression of CD20 or HLA\u2010A*02:01, or mutations in the CD20 sequence. Peptide pulsing fully restored the levels of cytotoxicity, indicating that they are indeed susceptible to T cell\u2010mediated killing. Adoptive transfer of CD20\u2010specific T cells to an HLA\u2010A*02:01<jats:sup>pos<\/jats:sup> patient requires an HLA\u2010A*02:01<jats:sup>neg<\/jats:sup>, but otherwise HLA identical, donor. A search clarified that donors meeting these criteria can be readily identified even for patients with rare haplotypes. The results bear further promise for the clinical utility of CD20\u2010specific T cells in B cell malignancies.<\/jats:p>","DOI":"10.1002\/ijc.26209","type":"journal-article","created":{"date-parts":[[2011,5,31]],"date-time":"2011-05-31T13:23:12Z","timestamp":1306848192000},"page":"1821-1832","source":"Crossref","is-referenced-by-count":8,"title":["T cells raised against allogeneic HLA\u2010A2\/CD20 kill primary follicular lymphoma and acute lymphoblastic leukemia cells"],"prefix":"10.1002","volume":"130","author":[{"given":"Ingerid 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