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We have isolated and characterized the exosomes generated from LAMA84 CML cells and demonstrated that addition of exosomes to human vascular endothelial cells (HUVEC) induces an increase of both ICAM\u20101 and VCAM\u20101 cell adhesion molecules and interleukin\u20108 expression. The stimulation of cell\u2010cell adhesion molecules was paralleled by a dose\u2010dependent increase of adhesion of CML cells to a HUVEC monolayer. We further showed that the treatment with exosomes from CML cells caused an increase in endothelial cell motility accompanied by a loss of VE\u2010cadherin and \u03b2\u2010catenin from the endothelial cell surface. Functional characterization of exosomes isolated from CML patients confirmed the data obtained with exosomes derived from CML cell line. CML exosomes caused reorganization into tubes of HUVEC cells cultured on Matrigel. When added to Matrigel plugs <jats:italic>in vivo<\/jats:italic>, exosomes induced ingrowth of murine endothelial cells and vascularization of the Matrigel plugs. Our results suggest for the first time that exosomes released from CML cells directly affect endothelial cells modulating the process of neovascularization.<\/jats:p>","DOI":"10.1002\/ijc.26217","type":"journal-article","created":{"date-parts":[[2011,5,31]],"date-time":"2011-05-31T13:23:39Z","timestamp":1306848219000},"page":"2033-2043","source":"Crossref","is-referenced-by-count":184,"title":["Role of exosomes released by chronic myelogenous leukemia cells in angiogenesis"],"prefix":"10.1002","volume":"130","author":[{"given":"Simona","family":"Taverna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Flugy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Saieva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise 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