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Although Snai1 has been investigated in a number of cancers, our knowledge on Snai2 and its role(s) in squamous cell carcinoma of oral tongue (SCCOT) is limited. In this study, we confirmed the previous observation that over\u2010expression of Snai2 is a frequent event in SCCOT. We further demonstrated that Snai2 over\u2010expression is associated with lymph node metastasis in two independent SCCOT patient cohorts (total <jats:italic>n<\/jats:italic> = 129). Statistical analysis revealed that Snai2 over\u2010expression was correlated with reduced overall survival. Furthermore, over\u2010expression of Snai2 was correlated with reduced E\u2010cadherin expression and enhanced Vimentin expression, suggesting a functional role of Snai2 in EMT. These observations were confirmed <jats:italic>in vitro<\/jats:italic>, in which knockdown of Snai2 induced a switch from a mesenchymal\u2010like morphology to an epithelial\u2010like morphology in SCCOT cell lines, and suppressed the cell invasion and migration. In contrast, ectopic transfection of Snai2 led to enhanced cell invasion and migration. Furthermore, Snai2 knockdown attenuated TGF\u03b21\u2010induced EMT in SCCOT cell lines. Taken together, these data suggest that Snai2 plays major roles in EMT and the progression of SCCOT and may serve as a therapeutic target for patients at risk of metastasis.<\/jats:p>","DOI":"10.1002\/ijc.26226","type":"journal-article","created":{"date-parts":[[2011,6,6]],"date-time":"2011-06-06T17:15:30Z","timestamp":1307380530000},"page":"2249-2258","source":"Crossref","is-referenced-by-count":47,"title":["Deregulation of Snai2 is associated with metastasis and poor prognosis in tongue squamous cell carcinoma"],"prefix":"10.1002","volume":"130","author":[{"given":"Cheng","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiqiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongzhang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huibin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weixin","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingsong","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianwei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,8,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-005-5051-5"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80333-2"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000161338.54515.b1"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(86)90305-3"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880140504"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(98)00294-3"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-007-9082-y"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.03.027"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.11.007"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39104"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2008.30"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1486806"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2009.160"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2008.11.021"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01907"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm757"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-0932"},{"key":"e_1_2_6_19_2","first-page":"1133","article-title":"Epithelial\u2013mesenchymal 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