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Our previous results show a positive association between red and processed meat and non cardia gastric cancer, especially in <jats:italic>Helicobacter pylori<\/jats:italic> infected subjects. The aim of the study is to investigate the association between heme iron intake and GC risk in the European prospective investigation into cancer and nutrition (EURGAST\u2010EPIC). Dietary intake was assessed by validated center\u2010specific questionnaires. Heme iron was calculated as a type\u2010specific percentage of the total iron content in meat intake, derived from the literature. Antibodies of <jats:italic>H. pylori<\/jats:italic> infection and vitamin C levels were measured in a sub\u2010sample of cases and matched controls included in a nested case\u2010control study within the cohort. The study included 481,419 individuals and 444 incident cases of GC that occurred during an average of 8.7 years of followup. We observed a statistically significant association between heme iron intake and GC risk (HR 1.13 95% CI: 1.01\u20131.26 for a doubling of intake) adjusted by sex, age, BMI, education level, tobacco smoking and energy intake. The positive association between heme iron and the risk of GC was statistically significant in subjects with plasma vitamin C &lt;39 mmol\/l only (log2 HR 1.54 95% CI (1.01\u20132.35). We found a positive association between heme iron intake and gastric cancer risk.<\/jats:p>","DOI":"10.1002\/ijc.26263","type":"journal-article","created":{"date-parts":[[2011,6,30]],"date-time":"2011-06-30T15:01:18Z","timestamp":1309446078000},"page":"2654-2663","source":"Crossref","is-referenced-by-count":39,"title":["Dietary intake of heme iron and risk of gastric cancer in the European prospective investigation into cancer and nutrition study"],"prefix":"10.1002","volume":"130","author":[{"given":"Paula","family":"Jakszyn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Agudo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Lujan\u2010Barroso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H Bas","family":"Bueno\u2010de\u2010Mesquita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazda","family":"Jenab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Palli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiner","family":"Boeing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Manjer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattijs E","family":"Numans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laszlo","family":"Igali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Christine","family":"Boutron\u2010Ruault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Clavel\u2010Chapelon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Morois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Grioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"cSalvatore","family":"Panico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Tumino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlotta","family":"Sacerdote","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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