{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T08:13:28Z","timestamp":1781597608147,"version":"3.54.5"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2011,8,24]],"date-time":"2011-08-24T00:00:00Z","timestamp":1314144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2012,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Metachronous gastric cancer (MGC) after endoscopic resection (ER) of gastric cancer still occurs to some degree even after <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H. pylori<\/jats:italic>) treatment. We evaluated whether two biomarkers related to carcinogenesis expressed in intestinal metaplasia (IM) become predictors for MGC development after eradication. We performed a hospital\u2010based, case\u2013control study of 75 patients, including 50 mucosal cancer patients who had undergone ER (Group DYS), and 25 age\u2010 and sex\u2010matched chronic gastritis patients for whom <jats:italic>H. pylori<\/jats:italic> had been successfully eradicated (control). Additionally, Group DYS patients were divided into two groups: 25 successfully <jats:italic>H. pylori<\/jats:italic>\u2010eradicated (eradicated group) and 25 un\u2010eradicated patients (persistent group). All patients were followed for 1 year. We analyzed microsatellite instability (MSI) and immunoperoxidase assays using a monoclonal antibody for the colonic phenotype (Das\u20101). Both MSI and Das\u20101 reactivity in IM were significantly higher in Group DYS than in the control (<jats:italic>p<\/jats:italic> &lt; 0.05 and <jats:italic>p<\/jats:italic> &lt; 0.01, respectively). MSI and Das\u20101 reactivity were strong and independent predictors for gastric cancer (OR = 7.09, 95% CI 1.27\u201339.6, <jats:italic>p<\/jats:italic> = 0.03 for MSI and OR = 4.96, 95% CI 1.64\u201315.0, <jats:italic>p<\/jats:italic> = 0.005 for Das\u20101 reactivity). The incidence of MSI tended to decrease in the eradicated group (<jats:italic>p<\/jats:italic> = 0.07), but not in the persistent group. The Das\u20101 immunoreactivity in IM also declined in both the eradicated group and the control. Interestingly, all MGCs after ER were positive for MSI or Das\u20101 reactivity. MSI or Das\u20101 reactivity in IM strongly predicts the development of MGC. Patients in whom these biomarkers persist after eradication may therefore have a high risk of developing MGC.<\/jats:p>","DOI":"10.1002\/ijc.26275","type":"journal-article","created":{"date-parts":[[2011,7,5]],"date-time":"2011-07-05T13:09:28Z","timestamp":1309871368000},"page":"2349-2358","source":"Crossref","is-referenced-by-count":21,"title":["Biomarkers predicting development of metachronous gastric cancer after endoscopic resection: an analysis of molecular pathology of <i>Helicobacter pylori<\/i> eradication"],"prefix":"10.1002","volume":"130","author":[{"given":"Jiro","family":"Watari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":", Kentaro","family":"Moriichi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":", Hiroki","family":"Tanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Kashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikihiro","family":"Fujiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Tomita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadayuki","family":"Oshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Fukui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Miwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiron M.","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Kohgo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,8,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/apm.1965.64.1.31"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19901215)66:12<2569::AID-CNCR2820661220>3.0.CO;2-I"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529309098333"},{"key":"e_1_2_6_5_2","series-title":"IARC monographs on the evaluation of carcinogenic risks to humans. Schistosomes, liver flukes and Helicobacter pylori","first-page":"177","author":"International Agency for Research on Cancer","year":"1994"},{"issue":"12","key":"e_1_2_6_6_2","first-page":"90","article-title":"Helicobacter pylori infection is the primary cause of gastric cancer","volume":"35","author":"Graham DY","year":"2000","journal-title":"J Gastroenterol"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa001999"},{"key":"e_1_2_6_8_2","first-page":"S37","article-title":"Helicobacter pylori and gastric carcinogenesis","volume":"19","author":"Correa P","year":"1995","journal-title":"Am J Surg Pathol"},{"key":"e_1_2_6_9_2","first-page":"3554","article-title":"A human model of gastric carcinogenesis","volume":"48","author":"Correa P","year":"1988","journal-title":"Cancer Res"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910570306"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.19.1607"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41384.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.2.187"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61159-9"},{"key":"e_1_2_6_15_2","first-page":"6735","article-title":"Human gastric carcinogenesis: a multistep and multifactorial process, First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention","volume":"52","author":"Correa P","year":"1992","journal-title":"Cancer Res"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1998.tb00514.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/25292"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.00045.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1309\/DFLELPGPNV5LK6B1"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20011120)95:6<350::AID-IJC1061>3.0.CO;2-A"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603532"},{"key":"e_1_2_6_22_2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.4049\/jimmunol.139.1.77","article-title":"The production and characterization of monoclonal antibodies to a human colonic antigen associated with ulcerative colitis: cellular localization of the antigen by using the monoclonal antibody","volume":"139","author":"Das KM","year":"1987","journal-title":"J Immunol"},{"key":"e_1_2_6_23_2","first-page":"212","volume-title":"Gastric carcinoma","author":"Filipe MI","year":"1986"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.6.807"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.12.044"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.127167"},{"key":"e_1_2_6_27_2","volume-title":"The general rules for gastric cancer study","author":"Japanese Research Society for Gastric Cancer","year":"1993"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24092"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.17.3415"},{"key":"e_1_2_6_30_2","first-page":"5248","article-title":"National Cancer Institute on Workshop on Microsatellite instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer","volume":"58","author":"Boland CR","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.6.821"},{"key":"e_1_2_6_32_2","first-page":"148","article-title":"Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences","volume":"145","author":"Kim H","year":"1994","journal-title":"Am J Pathol"},{"key":"e_1_2_6_33_2","first-page":"1166","article-title":"Low\u2010level microsatellite instability in most colorectal carcinomas","volume":"62","author":"Laiho P","year":"2002","journal-title":"Cancer Res"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-120-9-199405010-00006"},{"key":"e_1_2_6_35_2","first-page":"4662","article-title":"Microsatellite instability\u2010associated mutations associate preferentially with the intestinal type of primary gastric carcinomas in a high\u2010risk population","volume":"56","author":"Chung YJ","year":"1996","journal-title":"Cancer Res"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199706)182:2<167::AID-PATH830>3.0.CO;2-5"},{"key":"e_1_2_6_37_2","first-page":"1237","article-title":"Microsatellite instability in nonneoplastic mucosa from patients with chronic ulcerative colitis","volume":"56","author":"Brentnall TA","year":"1996","journal-title":"Cancer Res"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2000.19797"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.1999.1154"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPNP7BK3KUUOJL"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPCF25WBCGNEEZ"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2000.16669"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH631>3.0.CO;2-2"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-003-1260-2"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-011-4882-5_35"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.26275","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.26275","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T12:07:53Z","timestamp":1697458073000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.26275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,24]]},"references-count":44,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,5,15]]}},"alternative-id":["10.1002\/ijc.26275"],"URL":"https:\/\/doi.org\/10.1002\/ijc.26275","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,24]]}}}