{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:34:14Z","timestamp":1790793254690,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,8,29]],"date-time":"2011-08-29T00:00:00Z","timestamp":1314576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The nuclear factor kappa B (NF\u03baB) pathway is essential for many human cancers. Therapeutics such as bortezomib (Velcade\u2122) that interfere with NF\u03baB signaling are of great clinical interest. NF\u03baB signaling, however, is multifaceted and variable among tissues, developmental and disease entities. Hence, targeted biomarkers of NF\u03baB pathways are of prime importance for clinical research. We developed a novel real\u2010time qPCR\u2010based NF\u03baB array. Only mechanistically validated NF\u03baB targets were included. We then used random\u2010forest classification to define individual genes and gene combinations within the NF\u03baB pathways that define viral lymphoma subclasses as well as Kaposi sarcoma (KS). Few NF\u03baB targets emerged that were universally present in all tumor types tested, underscoring the need for additional tumor\u2010type specific biomarker discovery. (i) We uncovered tissue of origin\u2010specific tumor markers, specifically CD69, CSF\u20101 and complement factor B (C1QBP) for primary effusion lymphoma (PEL); IL1\u2010beta, cyclinD3 and CD48 for KS. We found that IL12, jun\u2010B, msx\u20101 and thrombospondin 2 were associated with EBV co\u2010infection in PEL. (ii) We defined the NF\u03baB signature of Epstein\u2013Barr virus (EBV) positive AIDS\u2010associated Burkitt lymphoma (BL). This signature identified CCR5 as the key marker. (iii) This signature differed from EBV negative BL consistent with the idea that EBV not only activates NF\u03baB activity but that this virus also reprograms NF\u03baB signaling toward different targets.<\/jats:p>","DOI":"10.1002\/ijc.26302","type":"journal-article","created":{"date-parts":[[2011,7,26]],"date-time":"2011-07-26T14:00:09Z","timestamp":1311688809000},"page":"2728-2733","source":"Crossref","is-referenced-by-count":16,"title":["Nuclear factor kappa B pathway associated biomarkers in AIDS defining malignancies"],"prefix":"10.1002","volume":"130","author":[{"given":"Juan\u2010Carlos","family":"Ramos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010Hoon","family":"Sin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle 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