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AT9283, a pan\u2010aurora inhibitor inhibited growth and survival of multiple solid tumors <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>. In this study, we demonstrated that AT9283 had potent activity against Aurora B in a variety of aggressive B\u2010(non\u2010Hodgkin lymphoma) B\u2010NHL cell lines. Cells treated with AT9283 exhibited endoreduplication confirming the mechanism of action of an Aurora B inhibitor. Also, treatment of B\u2010NHL cell lines with AT9283 induced apoptosis in a dose and time dependent manner and inhibited cell proliferation with an IC<jats:sub>50<\/jats:sub> &lt; 1 \u03bcM. It is well known that inhibition of auroras (A or B) synergistically enhances the effects of microtubule targeting agents such as taxanes and vinca alkaloids to induce antiproliferation and apoptosis. We evaluated whether AT9283 in combination with docetaxel is more efficient in inducing apoptosis than AT9283 or docetaxel alone. At very low doses (5 nM) apoptosis was doubled in the combination (23%) compared to AT9283 or docetaxel alone (10%). A mouse xenograft model of mantle cell lymphoma demonstrated that AT9283 at 15 mg\/kg and docetaxel (10 mg\/kg) alone had modest anti\u2010tumor activity. However, AT9283 at 20 mg\/kg and AT9283 (15 or 20 mg\/kg) plus docetaxel (10 mg\/kg) demonstrated a statistically significant tumor growth inhibition and enhanced survival. Together, our results suggest that AT9283 plus docetaxel may represent a novel therapeutic strategy in B\u2010cell NHL and warrant early phase clinical trial evaluation.<\/jats:p>","DOI":"10.1002\/ijc.26324","type":"journal-article","created":{"date-parts":[[2011,7,27]],"date-time":"2011-07-27T18:50:07Z","timestamp":1311792607000},"page":"2997-3005","source":"Crossref","is-referenced-by-count":48,"title":["AT9283, a novel aurora kinase inhibitor, suppresses tumor growth in aggressive B\u2010cell lymphomas"],"prefix":"10.1002","volume":"130","author":[{"given":"Wenqing","family":"Qi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence S.","family":"Cooke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel 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