{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:48:44Z","timestamp":1789609724067,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,8,30]],"date-time":"2011-08-30T00:00:00Z","timestamp":1314662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Risk of recurrent CIN2+ (including cervical intraepithelial neoplasia grade 2 [CIN2], CIN3, carcinoma and <jats:italic>in situ<\/jats:italic>, adenocarcinoma <jats:italic>in situ<\/jats:italic> or cancer) remains elevated for years following treatment. The role of long\u2010term post\u2010treatment human papillomavirus (HPV) presence on subsequent risk of CIN2+ was evaluated in the 10,049\u2010women Guanacaste cohort. Six hundred eighty\u2010one women were referred to colposcopy because of high\u2010grade cytology, positive cervicography and\/or suspicion of cancer based on visual assessment; 486 were judged to require treatment. After excluding women with &lt;12 months of follow\u2010up (<jats:italic>N<\/jats:italic> = 88), prior cancer or hysterectomy (<jats:italic>N<\/jats:italic> = 37) or other reasons (<jats:italic>N<\/jats:italic> = 14), 347 were included in the analysis. Infections were categorized as persistent if present at both pre\u2010 and post\u2010treatment visits and new if detected only post\u2010treatment. Median time between the treatment and post\u2010treatment visits was 6.7 years (interquartile range 3.8\u20137.8). At the post\u2010treatment visit, 8 (2.4%), 2 (0.6%) and 8 (2.4%) of the 347 treated women had persistent HPV16, HPV18 or other carcinogenic HPV, respectively. Two (0.8%), 3 (1.0%) and 13 (4.0%) had new HPV16, HPV18 and other carcinogenic HPV, respectively. Six CIN2+ cases were identified at the post\u2010treatment visit, all with persistent infections (three HPV16, one HPV18 and two other carcinogenic HPV). No recurrent disease was observed among women with new HPV infections during the follow\u2010up period. Thus, persistence of HPV infection a median of six years after treatment was uncommon but, when present, posed a substantial risk of subsequent CIN2+. Serial follow\u2010up data from other studies would further strengthen these conclusions.<\/jats:p>","DOI":"10.1002\/ijc.26349","type":"journal-article","created":{"date-parts":[[2011,8,5]],"date-time":"2011-08-05T15:16:59Z","timestamp":1312557419000},"page":"211-218","source":"Crossref","is-referenced-by-count":35,"title":["Long\u2010term risk of recurrent cervical human papillomavirus infection and precancer and cancer following excisional treatment"],"prefix":"10.1002","volume":"131","author":[{"given":"Aim\u00e9e 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