{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T02:29:13Z","timestamp":1788575353704,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,10,23]],"date-time":"2011-10-23T00:00:00Z","timestamp":1319328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In the Phase III PATRICIA study (NCT00122681), the human papillomavirus (HPV)\u201016\/18 AS04\u2010adjuvanted vaccine (\n                    <jats:italic>Cervarix<\/jats:italic>\n                    <jats:sup>\u00ae<\/jats:sup>\n                    , GlaxoSmithKline Biologicals) was highly efficacious against HPV\u201016\/18 infections and precancerous lesions in women HPV\u201016\/18 deoxyribose nucleic acid (DNA) negative and seronegative at baseline. We present further data on vaccine efficacy (VE) against HPV\u201016\/18 in the total vaccinated cohort including women who may have been exposed to HPV\u201016\/18 infection before vaccination. In women with no evidence of current or previous HPV\u201016\/18 infection (DNA negative and seronegative), VE was 90.3% (96.1% confidence interval: 87.3\u201392.6) against 6\u2010month persistent infection (PI), 91.9% (84.6\u201396.2) against cervical intraepithelial neoplasia (CIN)1+ and 94.6% (86.3\u201398.4) against CIN2+ [97.7% (91.1\u201399.8) when using the HPV type assignment algorithm (TAA)]. In women HPV\u201016\/18 DNA negative but with serological evidence of previous HPV\u201016\/18 infection (seropositive), VE was 72.3% (53.0\u201384.5) against 6\u2010month PI, 67.2% (10.9\u201389.9) against CIN1+, and 68.8% (\u221228.3\u201395.0) against CIN2+ [88.5% (10.8\u201399.8) when using TAA]. In women with no evidence of current HPV\u201016\/18 infection (DNA negative), regardless of their baseline HPV\u201016\/18 serological status, VE was 88.7% (85.7\u201391.1) against 6\u2010month PI, 89.1% (81.6\u201394.0) against CIN1+ and 92.4% (84.0\u201397.0) against CIN2+ [97.0% (90.6\u201399.5) when using TAA]. In women who were DNA positive for one vaccine type, the vaccine was efficacious against the other vaccine type. The vaccine did not impact the outcome of HPV\u201016\/18 infections present at the time of vaccination. Vaccination was generally well tolerated regardless of the woman's HPV\u201016\/18 DNA or serological status at entry.\n                  <\/jats:p>","DOI":"10.1002\/ijc.26362","type":"journal-article","created":{"date-parts":[[2011,8,19]],"date-time":"2011-08-19T15:31:14Z","timestamp":1313767874000},"page":"106-116","source":"Crossref","is-referenced-by-count":122,"title":["Efficacy of the human papillomavirus (HPV)\u201016\/18 AS04\u2010adjuvanted vaccine in women aged 15\u201325 years with and without serological evidence of previous exposure to 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