{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:28:30Z","timestamp":1787617710445,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,10,20]],"date-time":"2011-10-20T00:00:00Z","timestamp":1319068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2012,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>XPA, a zinc\u2010finger DNA\u2010binding protein, play an important role in both global genome and transcription\u2010coupled repair pathways. XPA \u22124G&gt;A polymorphism was identified in the 5\u2032 noncoding region, located four nucleotides upstream of the ATG start codon. Previous studies have shown that this polymorphism may affect mRNA tertiary structure and stability and play a role in susceptibility to cancer. However, the results remained controversial. To derive a more precise estimation of association between this polymorphism and risk of different types of cancer, we performed a meta\u2010analysis based on 36 case\u2013control or case\u2013cohort studies, including a total of 11,700 cases and 15,033 controls. We used odds ratios with 95% confidence intervals to assess the strength of the association. Overall, no significantly elevated cancer risk was found in all genetic models when eligible studies were pooled into the meta\u2010analysis. In the stratified analyses, we found that individuals with A\u2010allele had a higher risk of lung cancer (AA <jats:italic>versus<\/jats:italic> GG: OR = 1.25, 95% CI = 1.09\u20131.43; recessive model: OR = 1.31, 95% CI = 1.16\u20131.48). When stratified by ethnicity, significantly elevated risks were observed among Asian populations (AA <jats:italic>versus<\/jats:italic> GG: OR = 1.31, 95% CI = 1.01\u20131.70; dominant model: OR = 1.14, 95% CI = 1.00\u20131.30). This meta\u2010analysis suggests that XPA \u22124G&gt;A polymorphism is associated with increased lung cancer risk and may be a low\u2010penetrant risk factor in Asian ethnicity for cancer development.<\/jats:p>","DOI":"10.1002\/ijc.26391","type":"journal-article","created":{"date-parts":[[2011,9,13]],"date-time":"2011-09-13T07:35:07Z","timestamp":1315899307000},"page":"488-496","source":"Crossref","is-referenced-by-count":24,"title":["Genetic variation of XPA gene and risk of cancer: A systematic review and pooled 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