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However, <jats:italic>MYC<\/jats:italic> aberrations are not limited to BLs and then have a negative prognostic impact. In this study, we investigated to which extent aberrant c\u2010Myc activity plays a functional role in other aNHL and whether it is independent from <jats:italic>MYC<\/jats:italic> translocations. Based on a combined microarray analysis of human germinal center (GC) B cells transfected with c\u2010Myc and 220 aNHLs cases, we developed a \u201cc\u2010Myc index.\u201d This index measures the extent to which lymphomas express c\u2010Myc responsive genes. It comprises genes that are affected in a variety of tumors compared to normal tissue. This supports the view that aberrant c\u2010Myc expression in GC B cells triggers a tumor\u2010like expression pattern. As expected, the \u201cc\u2010Myc index\u201d is very high in molecular Burkitt lymphoma (mBL), but more importantly also high within other aNHL. It constitutes a negative prognostic marker independent of established risk factors and of the presence of a <jats:italic>MYC<\/jats:italic> translocation. Our data provide new insights into the role of c\u2010Myc activity in different lymphomas and raises the question of treatment changes for those patients under risk.<\/jats:p>","DOI":"10.1002\/ijc.26423","type":"journal-article","created":{"date-parts":[[2011,9,12]],"date-time":"2011-09-12T17:30:41Z","timestamp":1315848641000},"source":"Crossref","is-referenced-by-count":17,"title":["High myc activity is an independent negative prognostic factor for diffuse large B cell 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