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We have used two BCR epitope mimicking peptides binding to the Burkitt's lymphoma cell lines CA46 and SUP\u2010B8. We proved their functionality by demonstrating calcium flux and BCR\u2010mediated endocytosis upon peptide receptor binding. Toxicity experiments <jats:italic>in vitro<\/jats:italic>\n<jats:italic>via<\/jats:italic> cross\u2010linking of the BCR with tetramerized epitope mimics lead to apoptosis in both cell lines but was far more effective in SUP\u2010B8 cells. We established a SUP\u2010B8\u2010based disseminated Burkitt's lymphoma model in NOD\/SCID mice. Treatment of tumor\u2010bearing mice with tetramerized epitope mimics had significant anti\u2010tumor effects <jats:italic>in vivo<\/jats:italic>. We conclude that peptide\u2010mediated, BCR\u2010targeted therapy is a promising approach which may be explored and further developed for application in highly aggressive lymphoma.<\/jats:p>","DOI":"10.1002\/ijc.26464","type":"journal-article","created":{"date-parts":[[2011,9,28]],"date-time":"2011-09-28T02:35:54Z","timestamp":1317177354000},"source":"Crossref","is-referenced-by-count":2,"title":["Anti\u2010tumor activity of a B\u2010cell receptor\u2010targeted peptide in a novel disseminated lymphoma xenograft 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