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This study evaluates the relevance of this SNP in advanced ovarian cancer. <jats:italic>FGFR4<\/jats:italic>\u2010genotype was analyzed in 236 patients recruited as part of the OVCAD project. Genotyping was performed on germ\u2010line DNA using a TaqMan based genotyping assay. Results were correlated with clinicopathological variables and survival. The <jats:italic>FGFR4<\/jats:italic> 388Arg genotype was significantly associated with prolonged progression\u2010free and overall survival (univariate: HR 0.68, <jats:italic>p<\/jats:italic> = 0.017; HR 0.49, <jats:italic>p<\/jats:italic> = 0.005; multivariate: HR 0.69, <jats:italic>p<\/jats:italic> = 0.025; HR 0.49, <jats:italic>p<\/jats:italic> = 0.006) though the positive prognostic value was restricted to patients without postoperative residual tumor. Indeed, there was a significant interaction between <jats:italic>FGFR4<\/jats:italic> genotype and residual tumor for overall survival. Furthermore, the <jats:italic>FGFR4<\/jats:italic> 388Arg genotype significantly correlated with platinum sensitivity in the same subgroup (multivariate OR 3.81 <jats:italic>p<\/jats:italic> = 0.004). <jats:italic>FGFR4<\/jats:italic> Arg388Gly genotype is an independent and strong context specific prognostic factor in patients with advanced ovarian cancer and could be used to predict platinum\u2010sensitivity.<\/jats:p>","DOI":"10.1002\/ijc.27329","type":"journal-article","created":{"date-parts":[[2011,10,27]],"date-time":"2011-10-27T11:51:31Z","timestamp":1319716291000},"source":"Crossref","is-referenced-by-count":28,"title":["Fibroblast growth factor receptor 4 gene (<i>FGFR4<\/i>) 388Arg allele predicts prolonged survival and platinum sensitivity in advanced ovarian 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