{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:58:03Z","timestamp":1787061483132,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,12,21]],"date-time":"2011-12-21T00:00:00Z","timestamp":1324425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Type 2 diabetes has been suggested as an independent risk factor for the development of hepatocellular carcinoma (HCC). However, the role of Type 2 diabetes on the development of HCC in the presence of chronic hepatitis B (CHB) remains inconclusive. We conducted this hospital\u2010based case\u2013control study to evaluate the roles of Type 2 diabetes in HCC development in patients with CHB. From January 2004 to December 2008, a total of 6,275 eligible consecutive patients with chronic hepatitis B virus (HBV) infection were recruited. A total of 1,105 of them were patients with HBV\u2010related HCC and 5,170 patients were CHB but without HCC. We used multivariate logistic regression models to investigate the association between Type 2 diabetes and HCC risk. The prevalence of Type 2 diabetes is higher among HCC patients without cirrhosis than among those with cirrhosis (12.1%\n                    <jats:italic>vs.<\/jats:italic>\n                    6.7%,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.003). Type 2 diabetes was associated with a significantly high risk of HCC in female patients after adjusting for age, family history of HCC, city of residence, hepatitis B e antigen and cirrhosis with an odds ratio (95% confidence interval, CI) of 1.9 (1.1\u20133.4). Restricted analyses among female patients without cirrhosis indicated that Type 2 diabetes was strongly associated with HCC risk with adjusted odds ratio (95% CI) of 5.6 (2.2\u201314.1). In conclusion, Type 2 diabetes is independently associated with the increased risk of HCC in female CHB patients. Female CHB patients with Type 2 diabetes are of a high HCC risk population and should be considered for HCC close surveillance program.\n                  <\/jats:p>","DOI":"10.1002\/ijc.27337","type":"journal-article","created":{"date-parts":[[2011,11,2]],"date-time":"2011-11-02T08:18:05Z","timestamp":1320221885000},"page":"1197-1202","source":"Crossref","is-referenced-by-count":37,"title":["Type 2 diabetes and hepatocellular carcinoma: A case\u2013control study in patients with chronic hepatitis B"],"prefix":"10.1002","volume":"131","author":[{"given":"Qiang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Wen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Bo","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Hong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang\u2010Shuang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Xian","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi\u2010Jun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,21]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.55.2.74"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.09.011"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.04.061"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010415)91:8<1479::AID-CNCR1155>3.0.CO;2-0"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastro.2004.09.018"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.10.065"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.052167"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.13.1096"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21208"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.36780"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-07-2806"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.711"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-1131"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/88.20.1472"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.18.1360"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)90585-7"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.09.014"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2007.03.025"},{"key":"e_1_2_5_20_2","first-page":"O\u2010314","article-title":"Association of type 2 diabetes and HBeAg negative with noncirrhotic hepatocellular carcinoma [Abstract]","volume":"1","author":"Li Q","year":"2007","journal-title":"Hepatol Int"},{"key":"e_1_2_5_21_2","volume-title":"Chinese food compostion table 2002 ed","author":"Yang Y","year":"2002"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840190629"},{"key":"e_1_2_5_23_2","volume-title":"Diseases of the liver and biliary tract. standardization of nomenclature, diagnostic criteria and prognosis","author":"Leevy CM","year":"1994"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.1870210502"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800600817"},{"key":"e_1_2_5_26_2","unstructured":"World Health Organization. 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