{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:05:11Z","timestamp":1790744711812,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,1,3]],"date-time":"2012-01-03T00:00:00Z","timestamp":1325548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2012,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Little is known about the etiology of hepatoblastoma. Because of the young age at diagnosis, several studies have looked at various birth characteristics. The purpose of our study was to investigate the incidence of hepatoblastoma in the Nordic countries and the association between selected birth characteristics and hepatoblastoma. Data from national cancer registries and birth registries in Denmark, Sweden, Norway and Finland 1985\u20132006 was used. Overall, 155 children with hepatoblastoma aged 0\u201314 years were included and individually matched to five controls drawn randomly from national population registries. The incidence rate of hepatoblastoma was 1.7 per million person\u2010years with a predominance of boys (1.5:1). Incidence rate was highest before the age of 1 year (8.3 per million person\u2010years). A higher risk of hepatoblastoma was found in children with birth weight &lt;1,500 g [odds ratio (OR) = 9.5; 95% confidence interval (CI): 2.3\u201338.2], born preterm in week 22\u201332 (OR = 4.5; CI: 1.8\u201311.5) and Apgar scores &lt;7 after 1 min (OR = 3.1; CI: 1.3\u20137.1) and 5 min (OR = 7.5; CI: 1.8\u201332.4). A doubling in risk was found in children who were large for gestational age (OR = 2.3; CI: 1.0\u20135.3). No associations were found with birth order, maternal age or maternal smoking. Our study indicates that intrauterine and\/or neonatal factors are associated with increased risk of hepatoblastoma. These may include low birth weight and asphyxia leading to neonatal intensive care. Alternatively, the factors may be a consequence of hepatoblastoma developing <jats:italic>in utero<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/ijc.27351","type":"journal-article","created":{"date-parts":[[2011,11,18]],"date-time":"2011-11-18T08:20:39Z","timestamp":1321604439000},"source":"Crossref","is-referenced-by-count":32,"title":["Hepatoblastoma in the Nordic countries"],"prefix":"10.1002","volume":"131","author":[{"given":"S.","family":"de Fine Licht","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.S.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.H.","family":"Rod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Schmiegelow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.M.","family":"L\u00e4hteenm\u00e4ki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Kogner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Tr\u00e4ger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Stokland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Sch\u00fcz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,3]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.05.011"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2008-0011"},{"key":"e_1_2_7_4_2","first-page":"227","volume-title":"The surgery of childhood tumors. Second corrected and enlarged edition. Liver tumors in children","author":"Grosfeld JL","year":"2008"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70008-3"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1633"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.04.019"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2004.10.024"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20061"},{"key":"e_1_2_7_10_2","first-page":"459","article-title":"Retrospective analysis of maternal and infant birth features of hepatoblastoma patients","volume":"17","author":"Pu CL","year":"2009","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-3069"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604335"},{"key":"e_1_2_7_13_2","unstructured":"International Agency for Research on Cancer. Part E Lifestyle factors: tobacco areca nut alcohol coal smoke and saltet fish. IARC monographs on the evaluation of carcinogenic risks to humans 2009 vol.100."},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwj104"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600774"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601651"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181a5a332"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.10176"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20357"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-006-0128-z"},{"key":"e_1_2_7_21_2","first-page":"516","article-title":"Hepatoblastoma and birth weight: too little, too big, or just right?","volume":"130","author":"Ross JA","year":"1997","journal-title":"J Pediatr"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20910"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007379029182"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1996.tb14164.x"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199901000-00008"},{"key":"e_1_2_7_26_2","unstructured":"German Childhood Cancer Registry. Annual Report 2006\/2007 2009."},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17550-8"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70239-7"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.03.008"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-200x.2000.01287.x"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2003.50027"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1981.tb00991.x"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2007.07.047"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02015780"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-872592"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2008.27.7.1095"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/rpd\/ncn303"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1080\/08880010490457213"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-09-1273"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a112684"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00051889"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30267"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1177\/096228029300200202"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.27351","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.27351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T17:12:11Z","timestamp":1697476331000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.27351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,3]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,8,15]]}},"alternative-id":["10.1002\/ijc.27351"],"URL":"https:\/\/doi.org\/10.1002\/ijc.27351","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,3]]}}}