{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:47:56Z","timestamp":1788263276699,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,1,3]],"date-time":"2012-01-03T00:00:00Z","timestamp":1325548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human leukocyte antigen (HLA)\u2010G acts as negative regulator of the immune responses and its expression in tumor cells may enable them to escape immunosurveillance. The purpose of this study was to investigate the influence of HLA\u2010G polymorphism on risk of high\u2010grade cervical intraepithelial neoplasia (HG\u2010CIN) and cervical cancer in a Canadian population. The authors have analyzed 1,372 women from participants recruited between 2001 and 2009 in the ongoing Biomarkers of Cervical Cancer Risk case\u2013control study. A total of 539 women with histologically confirmed HG\u2010CIN and invasive cancer formed the case series, and 833 women with normal cytology served as controls. Cervical specimens were tested for human papillomavirus (HPV) DNA using the MY09\/11 PCR protocol and HLA\u2010G alleles where determined using a direct DNA sequencing procedures. HLA\u2010G polymorphisms were not associated with HG\u2010CIN or HPV infection. However, the risk for invasive cancer was significantly increased with the homozygous genotypes HLA\u2010G*01:01:02 [odds ratio (OR) = 3.52, 95% confidence interval (CI): 1.43\u20138.61, <jats:italic>p<\/jats:italic> = 0.006], \u2212G*01:06 (OR = 19.1, 95% CI: 2.29\u2013159, <jats:italic>p<\/jats:italic> = 0.005) and \u2212G* 3\u2032UTR 14\u2010bp insertion (OR = 2.17, 95% CI: 1.10\u20134.27, <jats:italic>p<\/jats:italic> = 0.020), whereas, the heterozygotic form of the G*01:01:01 wild\u2010type allele was significantly associated with a reduced risk of invasive cancer (OR = 0.31, 95% CI: 0.16\u20130.59, <jats:italic>p<\/jats:italic> &lt; 0.0001) after adjusting for age, HPV infection and ethnicity. These associations were also observed with progression of disease from HG\u2010CIN to invasive cancer among HPV\u2010positive women. These results suggest that HLA\u2010G polymorphism is an independent risk factor for the development of invasive cervical cancer.<\/jats:p>","DOI":"10.1002\/ijc.27356","type":"journal-article","created":{"date-parts":[[2011,11,18]],"date-time":"2011-11-18T08:22:46Z","timestamp":1321604566000},"source":"Crossref","is-referenced-by-count":61,"title":["Human leukocyte antigen G polymorphism is associated with an increased risk of invasive cancer of the uterine cervix"],"prefix":"10.1002","volume":"131","author":[{"given":"Rhea","family":"Ferguson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnihotram 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