{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T16:58:44Z","timestamp":1765040324046},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,1,3]],"date-time":"2012-01-03T00:00:00Z","timestamp":1325548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2012,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human papillomavirus (HPV) is detected in nearly all cervical cancers and approximately half of vaginal cancers. However, vaginal cancer is an order of magnitude less common than cervical cancer, not only in the general population but also among women with HIV\/AIDS. It is interesting therefore that recent studies found that HPV was common in both normal vaginal and cervical tissue, with higher prevalence of nononcogenic HPV types in the vagina. In our investigation, we prospectively examined HPV infection in 86 HIV\u2010positive and 17 HIV\u2010negative women who underwent hysterectomy during follow\u2010up in a longitudinal cohort. Cervicovaginal lavage specimens were obtained semi\u2010annually and tested for HPV DNA by polymerase chain reaction. To address possible selection biases associated with having a hysterectomy, subjects acted as their own comparison group\u2014before <jats:italic>versus<\/jats:italic> after hysterectomy. The average HPV prevalence was higher in HIV\u2010positive than HIV\u2010negative women both before (59% <jats:italic>vs<\/jats:italic>. 12%; <jats:italic>p<\/jats:italic> &lt; 0.001) and after hysterectomy (56% <jats:italic>vs<\/jats:italic>. 6%; <jats:italic>p<\/jats:italic> &lt; 0.001). Multivariate random effects models (within\u2010individual comparisons) demonstrated significantly lower HPV prevalence [odds ratio (OR) = 0.71; 95% confidence interval (CI) = 0.59\u20130.85) after hysterectomy. The association of HPV prevalence with hysterectomy was similar among HIV\u2010positive and HIV\u2010negative women. However, hysterectomy had greater effects on oncogenic (OR = 0.48; 95% CI = 0.35\u20130.66) than nononcogenic HPV types (OR = 0.89; 95% CI = 0.71\u20131.11; <jats:italic>P<\/jats:italic><jats:sub>interaction<\/jats:sub> = 0.002). Overall, we observed greater reductions in oncogenic than nononcogenic HPV prevalence after hysterectomy. If correct, these data could suggest that oncogenic HPV have greater tropism for cervical compared to vaginal epithelium, consistent with the lower incidence of vaginal than cervical cancer.<\/jats:p>","DOI":"10.1002\/ijc.27363","type":"journal-article","created":{"date-parts":[[2011,11,28]],"date-time":"2011-11-28T10:53:43Z","timestamp":1322477623000},"page":"1472-1478","source":"Crossref","is-referenced-by-count":12,"title":["Cervicovaginal human papillomavirus (HPV)\u2010infection before and after hysterectomy: evidence of different tissue tropism for oncogenic and nononcogenic HPV types in a cohort of HIV\u2010positive and HIV\u2010negative women"],"prefix":"10.1002","volume":"131","author":[{"given":"Gypsyamber","family":"D'Souza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert 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