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Data on incident cases of bone tumours in 0\u201384 year olds in England, 1979\u20132003, were extracted from national cancer registration data. Incidence rates per million person\u2010years by 5\u2010year age\u2010group, sex, morphology and primary site were calculated and adjusted to the world standard population. Nine thousand one hundred forty\u2010six cases were identified giving an overall age\u2010standardized rate of 7.19 per million person\u2010years. The distribution by morphology was: osteosarcoma, 34.2%; chondrosarcoma, 27.2%; Ewing sarcoma, 19.3%; other, 19.4%. The distribution varied by age. Ewing sarcoma was most common in 0\u20139 year olds, osteosarcoma in 10\u201329 year olds and chondrosarcoma in 30\u201384 year olds. 29.2% of all tumours occurred in 0\u201324 year olds. Highest incidence of osteosarcoma and Ewing sarcoma in females was in 10\u201314 year olds. In males, peak incidence occurred at 15\u201319 years and exceeded that in females. Chondrosarcoma incidence steadily increased with age. The proportions of Ewing sarcomas occurring in respective bones were consistent with those of the adult skeleton by weight. In osteosarcoma tumours of long bones of lower limb were markedly over\u2010represented in the adolescent peak, being six times more than at any other site. Variation in incidence patterns with age and site suggests pubertal bone growth to be a key factor in osteosarcoma while different biological pathways could be relevant for Ewing sarcoma.<\/jats:p>","DOI":"10.1002\/ijc.27402","type":"journal-article","created":{"date-parts":[[2011,12,15]],"date-time":"2011-12-15T08:51:39Z","timestamp":1323939099000},"page":"1678-1685","source":"Crossref","is-referenced-by-count":54,"title":["The contrasting age\u2010incidence patterns of bone tumours in teenagers and young adults: Implications for aetiology"],"prefix":"10.1002","volume":"131","author":[{"given":"Ramandeep S.","family":"Arora","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Alston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim O.B.","family":"Eden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Geraci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian M.","family":"Birch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,18]]},"reference":[{"key":"e_1_2_6_2_2","series-title":"Cancer incidence in five continents","first-page":"781","author":"Parkin DM","year":"2002"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1093\/acprof:oso\/9780198520702.001.0001","volume-title":"Childhood cancer in Britain incidence, survival, mortality","author":"Stiller CA","year":"2007"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600647"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604080"},{"key":"e_1_2_6_6_2","first-page":"9","volume-title":"WHO classification of tumors. 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