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Toenail clippings from each hallux were obtained from 638 participants of the FINBAR (Factors Influencing the Barrett's Adenocarcinoma Relationship) study comprising 221 healthy controls, 98 reflux oesophagitis, 182 BO and 137 OAC cases. The concentrations of eight toenail trace elements were determined using instrumental neutron activation analysis. Using multivariable adjusted logistic regression analysis, odds ratios (OR) and 95% confidence intervals (CIs) were calculated within tertiles of trace element concentrations. A twofold increased risk of BO was observed, but not OAC, among individuals in the highest tertile of toenail zinc status OR 2.21 (95% CI, 1.11\u20134.40). A higher toenail selenium status was not associated with risk of OAC OR 0.94 (95% CI, 0.44\u20132.04) or BO OR 0.89 (95% CI, 0.37\u20132.12). A borderline significant increased risk of BO was detected with a higher toenail cobalt concentration, OR 1.97 (95% CI, 1.01\u20133.85). No association was found between toenail levels of chromium, cerium, mercury and OAC or BO risk. This is the first case\u2013control study to investigate a variety of trace elements in relation to OAC and BO risk. Despite antioxidant and proapoptotic properties, no associations were found with selenium. Higher concentrations of toenail zinc and cobalt were associated with an increased BO risk, but not OAC. These findings need confirmation in prospective analysis.<\/jats:p>","DOI":"10.1002\/ijc.27434","type":"journal-article","created":{"date-parts":[[2012,1,19]],"date-time":"2012-01-19T15:04:25Z","timestamp":1326985465000},"page":"1882-1891","source":"Crossref","is-referenced-by-count":25,"title":["Toenail trace element status and risk of Barrett's oesophagus and oesophageal adenocarcinoma: Results from the FINBAR study"],"prefix":"10.1002","volume":"131","author":[{"given":"Michael A.","family":"O'Rorke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie M.","family":"Cantwell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian C.","family":"Abnet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"and John D.","family":"Brockman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liam J.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the FINBAR Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,3,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn211"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23232"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji024"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605246"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365520600815654"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-011-9596-z"},{"key":"e_1_2_6_8_2","unstructured":"BerrinoF International agency for research on cancer and commission of the European communities survival of cancer patients in Europe: the EUROCARE\u20102 study International Agency for Research on Cancer 1999."},{"key":"e_1_2_6_9_2","first-page":"1","article-title":"Survival for cancer of the oesophagus in England and Wales up to 2001","volume":"99","author":"Mitry E","year":"2008","journal-title":"Br J Cancer"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-006-0057-z"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/26.2.43-a"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2010.02373.x"},{"key":"e_1_2_6_13_2","first-page":"493","article-title":"Toenail trace element levels as biomarkers: reproducibility over a 6\u2010year period","volume":"2","author":"Garland M","year":"1993","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2005.12.001"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1079\/PNS2005467"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/07388550802658048"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.12.004"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-010-9651-1"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2004.07.005"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-9444-1_3"},{"key":"e_1_2_6_21_2","unstructured":"Food and Agriculture Organisation of the United Nations & World Health Organisation (FAO\/WHO) Human vitamin & mineral requirements: report of a joint FAO\/WHO expert consultation Food & Nutrition Division Food and Agriculture Organisation of the United Nations 2001."},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1039\/c0nr00875c"},{"key":"e_1_2_6_23_2","first-page":"119","article-title":"Effect of cerium lanthanide on Hela and MCF\u20107 cancer cell growth in the presence of transferrin","volume":"5","author":"Palizban AA","year":"2010","journal-title":"Res Pharm Sci"},{"key":"e_1_2_6_24_2","unstructured":"Agency for Toxic Substances Disease Registry (ATSDR) Toxicological profile for Chromium US Department of Health and Human Services Public Health Service 2008."},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2010.03.013"},{"key":"e_1_2_6_26_2","unstructured":"Agency for Toxic Substances Disease Registry (ATSDR) Toxicological profile for Mercury US Department of Health & Social Services Public Health Service 1999."},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-4253"},{"key":"e_1_2_6_28_2","first-page":"95","article-title":"EPIC Norfolk: study design and characteristics of the cohort. 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