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MSCs are known to engraft at tumors and integrate into their architecture, potentially as carcinoma\u2010associated fibroblasts. In contrast with other malignancies, our understanding of the interactions between colorectal cancer cells and MSCs remains limited. Considering the established importance of inflammation in the colorectal cancer primary tumor microenvironment and the role of stromal cells in this process, there is a potential wealth of information to be gleaned from further investigation of interactions between these cell populations. Epithelial\u2013mesenchymal transition is central to colorectal cancer progression and MSCs have also been implicated in this process. This review explores the current knowledge (both <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>) of interactions between colorectal cancer cells and MSCs. It highlights potential effects of cell source, number and ratio on outcome of <jats:italic>in vivo<\/jats:italic> studies and explores strategies to more accurately explore their role in the primary tumor microenvironment. As our understanding of the underlying molecular processes in colorectal cancer develops, elucidation of these interactions will be central to development of novel therapeutic strategies for this prevalent disease.<\/jats:p>","DOI":"10.1002\/ijc.27458","type":"journal-article","created":{"date-parts":[[2012,1,30]],"date-time":"2012-01-30T17:25:34Z","timestamp":1327944334000},"page":"1-7","source":"Crossref","is-referenced-by-count":35,"title":["Mesenchymal stem cells in the colorectal tumor microenvironment: Recent progress and implications"],"prefix":"10.1002","volume":"131","author":[{"given":"Niamh M.","family":"Hogan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roisin M.","family":"Dwyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myles R.","family":"Joyce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael 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