{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T07:21:48Z","timestamp":1770276108565,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,3,15]],"date-time":"2012-03-15T00:00:00Z","timestamp":1331769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dichlorodiphenyltrichloroethane (<jats:italic>p,p<\/jats:italic>\u2032\u2010DDT), an organochlorine pesticide known to have deleterious health effects in humans, has been linked to hepatocellular carcinoma (HCC) in rodents. A recent study has reported that <jats:italic>p,p<\/jats:italic>\u2032\u2010DDT and its most persistent metabolite, dichlorodiphenyldichloroethylene (<jats:italic>p,p<\/jats:italic>\u2032\u2010DDE), may also be associated with HCC in humans. To examine whether there is an association between <jats:italic>p,p<\/jats:italic>\u2032\u2010DDT and\/or <jats:italic>p,p<\/jats:italic>\u2032\u2010DDE in a population at high\u2010risk of developing HCC, a nested case\u2013control study was conducted within the 83,794 person Haimen City Cohort in China. Sera and questionnaire data were collected from all participants between 1992 and 1993. This study included 473 persons who developed HCC and 492 who did not, frequency matched on sex, age and area of residence. <jats:italic>p,p<\/jats:italic>\u2032\u2010DDT and <jats:italic>p,p<\/jats:italic>\u2032\u2010DDE levels were determined by mass spectrometry. Hepatitis B viral infection status (based on hepatitis B virus surface antigen; HBsAg) was also determined. <jats:italic>p,p<\/jats:italic>\u2032\u2010DDT and\/or <jats:italic>p,p<\/jats:italic>\u2032\u2010DDE serum levels were significantly associated with sex, area of residence, occupation, alcohol consumption and cigarette smoking. Adjusting for age, sex, area of residence, HBsAg, family history of HCC, history of acute hepatitis, smoking, alcohol, occupation (farmer <jats:italic>vs.<\/jats:italic> other) and levels of <jats:italic>p,p<\/jats:italic>\u2032\u2010DDT or <jats:italic>p,p<\/jats:italic>\u2032\u2010DDE, odds ratios (OR) and 95% confidence intervals (CI) were calculated <jats:italic>via<\/jats:italic> unconditional logistic regression. Overall, the highest quintile of <jats:italic>p,p<\/jats:italic>\u2032\u2010DDT was associated with an increased risk of HCC, OR = 2.96 95% CI; 1.19\u20137.40. There were no statistically significant associations with <jats:italic>p,p<\/jats:italic>\u2032\u2010DDE. Overall, these results suggest that recent exposure to <jats:italic>p,p<\/jats:italic>\u2032\u2010DDT may increase risk of HCC.<\/jats:p>","DOI":"10.1002\/ijc.27459","type":"journal-article","created":{"date-parts":[[2012,1,30]],"date-time":"2012-01-30T17:25:41Z","timestamp":1327944341000},"page":"2078-2084","source":"Crossref","is-referenced-by-count":45,"title":["Dichlorodiphenyltrichloroethane and risk of hepatocellular carcinoma"],"prefix":"10.1002","volume":"131","author":[{"given":"E. Christina","family":"Persson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry I.","family":"Graubard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison A.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. 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