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In this review, we use a reverse bedside\u2010to\u2010bench approach to investigate the effects of common cardiovascular medications on tumor angiogenesis and vascular angiogenesis. Aspirin seems to reduce the risk of developing cancer, particularly colon cancer. However, whether the protective influence of aspirin is due to antiangiogenesis effect is still unclear. \u03b2\u2010Blockers, which are normally used to reduce heart rate and prolong diastole, trigger an increase in stretch\u2010associated release of proangiogenic growth factors thereby inducing angiogenesis. However, according to other studies \u03b2\u2010blockers are able to inhibit angiogenesis <jats:italic>via<\/jats:italic> multiplicate mechanisms. Similarly, angiotensin converting enzyme inhibitor and angiotensin II type 1 receptor blocker have controversial effects for the regulation of cell proliferation and angiogenesis. Statins can augment collateral vascular growth in ischemic tissues and restrict the development of cancer. So this topical anti\u2010inflammatory drug seems to be of high value for further therapy. Finally, suggestions on how this pilot experience may guide the conduct of future preclinical investigations, and clinical trials are discussed.<\/jats:p>","DOI":"10.1002\/ijc.27576","type":"journal-article","created":{"date-parts":[[2012,4,5]],"date-time":"2012-04-05T10:55:04Z","timestamp":1333623304000},"page":"1249-1259","source":"Crossref","is-referenced-by-count":7,"title":["Cardiovascular medications in angiogenesis\u2014How to avoid the sting in the 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