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The activated astrocyte by N\u2010inv, thus, may affect cachexia in pancreatic cancer. Clinical studies in patients and autopsy cases with pancreatic cancer have revealed that N\u2010inv is related to cachexia and astrocytic activation. We established a novel murine model of cancer cachexia using N\u2010inv of human pancreatic cancer cells. Mice with N\u2010inv showed a loss of body weight, skeletal muscle and fat mass without appetite loss, which are compatible with an animal model of cancer cachexia. Activation of astrocytes in the spinal cord connected with N\u2010inv was observed in our model. Experimental cachexia was suppressed by disrupting neural routes or inhibiting the activation of astrocytes. These data provide the first evidence that N\u2010inv induces cachexia <jats:italic>via<\/jats:italic> astrocytic activation of neural route in pancreatic cancer.<\/jats:p>","DOI":"10.1002\/ijc.27594","type":"journal-article","created":{"date-parts":[[2012,4,17]],"date-time":"2012-04-17T11:53:00Z","timestamp":1334663580000},"page":"2795-2807","source":"Crossref","is-referenced-by-count":28,"title":["Neural invasion induces cachexia <i>via<\/i> astrocytic activation of neural route in pancreatic 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