{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:59:50Z","timestamp":1762865990426},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:00:00Z","timestamp":1340841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2013,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We explored potential associations between genetic polymorphisms in genes related to DNA repair and detoxification metabolism and epidermal growth factor receptor (<jats:italic>EGFR<\/jats:italic>) mutations in a cohort of 410 never\u2010smoking patients with lung adenocarcinoma. Multivariate\u2010adjusted odds ratios (aORs) and corresponding 95% confidence intervals (CI) of <jats:italic>EGFR<\/jats:italic> mutation status in association with the genotypes of DNA repair and detoxification metabolism genes were evaluated using logistic regression analysis. We found an association between in\u2010frame deletion in <jats:italic>EGFR<\/jats:italic> exon 19 and a single nucleotide polymorphism (SNP) rs1800566C\/T located in <jats:italic>NQO1<\/jats:italic> (aOR, 2.2 with 95% CI, 1.0\u20134.8) in female never\u2010smokers. The SNP rs744154C\/G in <jats:italic>ERCC4<\/jats:italic> was also associated with the <jats:italic>EGFR<\/jats:italic> exon 19 in\u2010frame deletion both in never\u2010smokers (aOR, 1.7 with 95% CI, 1.0\u20133.0) and female never\u2010smokers (aOR, 1.9 with 95% CI, 1.0\u20133.6). Although the association was marginally significant in multivariate logistic regression analysis, the A\/A genotype of rs1047840 in <jats:italic>EXO1<\/jats:italic> was associated with a 7.6\u2010fold increase in the occurrence of the <jats:italic>EGFR<\/jats:italic> exon 19 in\u2010frame deletion in female never\u2010smokers. Moreover, risk alleles in <jats:italic>NQO1<\/jats:italic>, <jats:italic>ERCC4<\/jats:italic> and <jats:italic>EXO1<\/jats:italic> were associated with an increasing aOR of the <jats:italic>EGFR<\/jats:italic> exon 19 in\u2010frame deletion both in never\u2010smokers (<jats:italic>p<\/jats:italic> = 0.007 for trend) and female never\u2010smokers (<jats:italic>p<\/jats:italic> = 0.002 for trend). Our findings suggest that the in\u2010frame deletion in <jats:italic>EGFR<\/jats:italic> exon 19 is associated with polymorphisms in DNA repair and detoxification metabolism genes in never\u2010smoking lung adenocarcinoma patients, especially in females.<\/jats:p>","DOI":"10.1002\/ijc.27630","type":"journal-article","created":{"date-parts":[[2012,5,10]],"date-time":"2012-05-10T07:02:59Z","timestamp":1336633379000},"page":"449-458","source":"Crossref","is-referenced-by-count":9,"title":["<i>EGFR<\/i> exon 19 in\u2010frame deletion and polymorphisms of DNA repair genes in never\u2010smoking female lung adenocarcinoma patients"],"prefix":"10.1002","volume":"132","author":[{"given":"Shi\u2010Yi","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsung\u2010Ying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao\u2010Jen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun\u2010Chieh","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuo\u2010Meng","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuo\u2010Hsuan","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi\u2010Ren","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Yi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung\u2010Ping","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiun\u2010Yi","family":"Hsia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng\u2010Yen","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying\u2010Huang","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuan\u2010Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Shyan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu\u2010Chou","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuh\u2010Min","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao A.","family":"Hsiung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen\u2010Yang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gee\u2010Chen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pan\u2010Chyr","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien\u2010Jen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,6,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2788"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.11.069"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099314"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2006.04.022"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1417406"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1101637"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji055"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/75586"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-2689"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1127515"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgr117"},{"key":"e_1_2_6_13_2","volume-title":"DNA repair and mutagenesis","author":"Friedberg EC","year":"2006"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.36.040196.001223"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-2045"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-2797(00)00199-X"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/35077232"},{"key":"e_1_2_6_18_2","volume-title":"World Health Organization Classification of tumours, pathology and genetics of tumours of the lung, pleura, thymus, and heart","author":"Travis WD","year":"2004"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1931"},{"key":"e_1_2_6_20_2","first-page":"4103","article-title":"Reduced DNA repair capacity in lung cancer patients","volume":"56","author":"Wei Q","year":"1996","journal-title":"Cancer Res"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24746"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31817e4664"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/em.1037"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/geq008"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181e0b993"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/16.5.993"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-04-0640"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.59.2.263"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2005.10.025"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1997.11"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.11.026"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-1418"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605416"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.427.2.8"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2007.11.003"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90546-3"},{"key":"e_1_2_6_37_2","first-page":"3012","article-title":"An intron splice acceptor polymorphism in hMSH2 and risk of leukemia after treatment with chemotherapeutic alkylating agents","volume":"9","author":"Worrillow LJ","year":"2003","journal-title":"Clin Cancer Res"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(97)00219-0"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7973733"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.10077"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25863"},{"key":"e_1_2_6_42_2","first-page":"2557","article-title":"XRCC1 polymorphisms: effects on aflatoxin B1\u2010DNA adducts and glycophorin A variant frequency","volume":"59","author":"Lunn RM","year":"1999","journal-title":"Cancer Res"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp019"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1080\/20024091064273"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:BREA.0000004376.21491.44"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-5030"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2858"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07943"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.2217\/14622416.10.3.489"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2008.00812.x"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-1773"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.27630","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.27630","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T15:52:43Z","timestamp":1697471563000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.27630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,28]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,1,15]]}},"alternative-id":["10.1002\/ijc.27630"],"URL":"https:\/\/doi.org\/10.1002\/ijc.27630","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,28]]}}}