{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T02:30:23Z","timestamp":1789957823321,"version":"4.0.1"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,6,13]],"date-time":"2012-06-13T00:00:00Z","timestamp":1339545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Testing for DNA of 13 high\u2010risk HPV types with the Hybrid Capture 2 (HC2) test has consistently been shown to perform better in triage of women with cervical cytology results showing atypical squamous cells of undetermined significance (ASC\u2010US) but often not in triage of low\u2010grade squamous intraepithelial lesions (LSIL) detected in cervical cancer screening. In a meta\u2010analysis, we compared the accuracy of the APTIMA HPV test, which identifies RNA of 14 high\u2010risk HPV types, to HC2 for the triage of women with ASC\u2010US or LSIL. Literature search\u2010targeted studies where the accuracy of APTIMA HPV and HC2 for detection of underlying CIN2\/3+ was assessed concomitantly including verification of all cases of ASC\u2010US and LSIL. HSROC (Hierarchical Summary ROC) curve regression was used to compute the pooled absolute and relative sensitivity and specificity. Eight studies, comprising 1,839 ASC\u2010US and 1,887 LSIL cases, were retrieved. The pooled sensitivity and specificity of APTIMA to triage ASC\u2010US to detect underlying CIN3 or worse was 96.2% (95% CI = 91.7\u201398.3%) and 54.9% (95% CI = 43.5\u201365.9%), respectively. APTIMA and HC2 showed similar pooled sensitivity; however, the specificity of the former was significantly higher (ratio: 1.19; 95% CI = 1.08\u20131.31 for CIN2+). The pooled sensitivity and specificity of APTIMA to triage LSIL were 96.7% (95% CI = 91.4\u201398.9%) and 38.7% (95% CI = 30.5\u201347.6%) for CIN3+. APTIMA was as sensitive as HC2 but more specific (ratio: 1.35; 95% CI = 1.11\u20131.66). Results were similar for detection of CIN2 or worse. In both triage of ASC\u2010US and LSIL, APTIMA is as sensitive but more specific than HC2 for detecting cervical precancer.<\/jats:p>","DOI":"10.1002\/ijc.27636","type":"journal-article","created":{"date-parts":[[2012,5,18]],"date-time":"2012-05-18T12:09:34Z","timestamp":1337342974000},"page":"101-108","source":"Crossref","is-referenced-by-count":120,"title":["The APTIMA HPV assay <i>versus<\/i> the hybrid capture 2 test in triage of women with ASC\u2010US or LSIL cervical cytology: A meta\u2010analysis of the diagnostic accuracy"],"prefix":"10.1002","volume":"132","author":[{"given":"Marc","family":"Arbyn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolien","family":"Roelens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Cuschieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Cuzick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Szarewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Ratnam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Reuschenbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Belinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome L.","family":"Belinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Monsonego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,13]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2008.00623.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2010.0103"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e3181bbb62e"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.07.047"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPQCIBCZ22ZIMG"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012724"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2546"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.326"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024083"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(98)00245-2"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.3.252"},{"key":"e_1_2_6_13_2","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1093\/clinchem\/44.6.1363","article-title":"Hybrid capture","volume":"44","author":"Lorincz AT","year":"1998","journal-title":"Clin Chem"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh037"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.05.117"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.06.019"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(03)00418-6"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(03)00413-7"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2005.07.033"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00631.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.11.013"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181e3e719"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(09)70007-1"},{"key":"e_1_2_6_24_2","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1001\/jama.1989.03430070079034","article-title":"National Cancer Institute. 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